Ring fused pyrazole derivatives as CRF antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S119000

Reexamination Certificate

active

07053103

ABSTRACT:
This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I or Formula II:wherein Ar is optionally substituted aryl or heteroaryl, R1–R4are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts thereof. The invention further relates to processes for preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for their use as therapeutic agents.

REFERENCES:
patent: 5668145 (1997-09-01), Bright
patent: 5705646 (1998-01-01), Bright et al.
patent: 5712303 (1998-01-01), Faraci et al.
patent: 5760225 (1998-06-01), Yuan
patent: 6200979 (2001-03-01), Bright et al.
Hehemann, et al., “Addition of Diamines to Methylthiopyridones,”J. Heterocyclic Chem., (1994), pp. 393-396, vol. 31 (2).
Mohareb, et al., “Reactions with 4-Phenyl-3-thiosemicarbazide: A New Approach for the Synthesis of Pyrazole, Thiazole, Pyridine and Pyrazolo[3,4-b]- Pyridine Derivatives,”Sulfur Letters, (1991), pp. 101-113, vol. 13 (3).
Chemstar Ltd, Moscow, Russia, Database Chemcats 'online! Chemical Abstracts Service, Columbus, Ohio, US; retrieved from STN XP-002233223, Order Nos.: CHS 0390519; CHS 0053761, dated May 16, 2001.
Asinex, Moscow, Russia, Database Chemcats 'online! Chemical Abstracts Service, Columbus, Ohio, US; retrieved from STN XP-002233224, Order No.: BAS 0138479, dated May 10, 2001.
Specs and Biospecs B.V., Rijswijk, NL, Database Chemcats 'online! Chemical Abstracts Service, Columbus, Ohio, US; retrieved from STN XP-002233225, Order No.: AG-667/12449002 & “Compounds for Screening”, dated Jul. 1, 2001.
Ambinter, Paris, France, Database Chemcats 'online! Chemical Abstracts Service, Columbus, Ohio, US; retrieved from STN XP-002233226, Order Nos.:132-45219; 132-45159; 132-45157; 132-45155; Stock1S-39093, Stock1S-34168; dated Jan. 21, 2002.

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