Ring E-modified analogues of(-)-podophyllotoxin and etoposide an

Details Ring E-modified analogues of(-)-podophyllotoxin and etoposide an Ring E-modified analogues of(-)-podophyllotoxin and etoposide an

1997-10-02

2000-04-18

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30777, C07D30780

Patent

active

060517212

ABSTRACT:
A process of preparing ring E-modified analogues of (-)-podophyllotoxin as potential new chemotherapeutic agents. The process generates corresponding analogues of (-)-podophyllotoxin, itself, and allows new molecular interactions in the southern hemisphere (ring E) of the molecule. A method of preparing enantiomerically enriched compounds of the formula (I) and (II): ##STR1## wherein R is: ##STR2## wherein X, X', Y, Y' and Z are ring E substituents and R.sup.1 is one of a)-e) below.

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