Ring-closing metathesis process in supercritical fluid

Details Ring-closing metathesis process in supercritical fluid Ring-closing metathesis process in supercritical fluid

2007-03-13

2007-03-13

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

11222882

ABSTRACT:
Disclosed is a process for preparing a compound of formula I comprising cyclizing a diene compound of formula III in the presence of a ruthenium catalyst in a suitable organic solvent, wherein the process is performed in a gaseous fluid at supercritical or near-supercritical conditions:The compounds of formula (I) are active agents for the treatment of hepatitis C viral (HCV) infections or are intermediates useful for the preparation of anti-HCV agents.

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Alois Furstner, et al, Olefin Metathesis in Supercritical Carbon Dioxide, J. Am. Chem. Soc. 2001, 123, 9000-9006.

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