Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1998-03-23
2000-02-08
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
534 14, 424 111, 424 153, A61K 5100, A61M 3614
Patent
active
06022522&
ABSTRACT:
Bicyclo[2.2.2]octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.
REFERENCES:
patent: 5783169 (1998-07-01), Sweet et al.
Mease Ronnie C.
Srivastava Suresh C.
Sweet Mark P.
Bogosian Margaret C.
Brookhaven Science Associates
Dees Jos,e G.
Jones Dameron
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