Rigid bifunctional chelating agents

Details Rigid bifunctional chelating agents Rigid bifunctional chelating agents

1995-07-26

1998-07-21

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 111, 534 10, 534 14, A61K 5100, A61M 3614

Patent

active

057831696

ABSTRACT:
chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

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Sweet et al. Abstract for Slide Presentation at 208 ACS National Meeting (NUCL 43), Aug. 22, (1994).
Mease et al. Development of Novel Bifunctional Chelating Agents Containing Rigid Cyclic Hydrocarbon Backbones, The Society of Nuclear Medicine 42nd Annual Meeting, Minneapolis, MN. No. 05226, Jun. 12-Jun. 15 (1995).

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