Rifamycins, their compositions and use as antibiotics

Details Rifamycins, their compositions and use as antibiotics Rifamycins, their compositions and use as antibiotics

1982-07-12

1983-10-25

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602393P, 435119, 435253, A61K 31395, C07D49108

Patent

active

044118961

ABSTRACT:
New antibiotically active compounds having the basic structure of rifamycin S, namely 3-hydroxyrifamycin S (formula A: X=>C.dbd.O; R.sup.1 =OH; R.sup.2 =H), 3,31-dihydroxy-rifamycin S (formula A: X=>C.dbd.O; R.sup.1 =R.sup.2 =OH) and 1-desoxy-1-oxarifamycin S (formula A: X=--O--; R.sup.1 =R.sup.2 =H) ##STR1## are formed by cultivating, under aerobic conditions, a strain of Nocardia mediterranei which is derived from Streptomyces mediterranei ATCC 13 685 as the parent strain and is characterized by the ability to produce at least one of the mentioned compounds. The recombinant strain Nocardia mediterranei DSM 1415 has proved suitable. The mentioned rifamycin S analogues have analogous antibiotic properties to this but have a wider range of action, especially against gram-negative bacteria.

REFERENCES:
Yang et al. "J. Nat. Cancer Institute", vol. 49, No. 1, Jul. 1972, pp. 7-25 (Note p. 14).

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