Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-07-03
2007-07-03
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S253080, C514S312000, C540S456000
Reexamination Certificate
active
11034279
ABSTRACT:
The present invention relates to rifamycin 3-iminomethylenyl (—CH═N—) derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. The claimed rifamycin derivative has a rifamycin moiety covalently linked to a linker through an iminomethylenyl (—CH═N—) group at the C-3 carbon of the rifamycin moiety and the linker is, in turn, covalently linked to a quinolone structure or its pharmacophore within the DNA gyrase and topoisomerase IV inhibitor family. The inventive rifamycins are novel and exhibit activity against both rifampin and ciprofloxacin-resistant microorganisms.
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patent: WO 03/045319 (2003-06-01), None
Brufani, M., et al; “Rifamycins: an Insight into Biological Activity Based on Structural Investigations”; J. Mol. Biol., 1974, vol. 87, pp. 409-435.
Mandell, Gerald L., et al.; “Rifamycins”; Principles and Practice of Infectious Diseases; pp. 348-361; Churchill Livingstone (2001).
Ding Charles Z.
Harran Susan
Jin Yafei
Kim In Ho
Li Jing
Cumbre Pharmaceuticals Inc.
Jackson Walker L.L.P.
Kifle Bruck
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