Rifamycin derivatives and process for their preparation

Details Rifamycin derivatives and process for their preparation Rifamycin derivatives and process for their preparation

1978-12-11

1980-04-29

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, C07D49108, A61K 3133

Patent

active

042005744

ABSTRACT:
8-amino and 8-iminorifamycins S and SV are prepared by reacting 8-methoxyrifamycin S with ammonia in an inert polar and hydrophillic solvent, converting the 8-iminorifamycin S into 8 aminorifamycin S by reaction with ammonium hydroxide in a mixture of chloroform and methanol and, if so desired, reducing the S forms to SV forms by reduction.

REFERENCES:
patent: 3342810 (1967-09-01), Maggi et al.
patent: 3349082 (1967-10-01), Maggi et al.

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