Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2008-05-20
2008-05-20
Carlson, Karen Cochrane (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
10394511
ABSTRACT:
The present invention provides a protein having an A chain of a ricin-like toxin, a B chain of a ricin-like toxin and a heterologous linker amino acid sequence, linking the A and B chains. The linker sequence contains a cleavage recognition site for a disease specific protease such as a cancer, fungal, viral or parasitic protease. The invention also relates to a nucleic acid molecule encoding the protein and to expression vectors incorporating the nucleic acid molecule. Also provided is a method of inhibiting or destroying mammalian cancer cells, cells infected with a virus, a fungus, or parasite; or parasites utilizing the nucleic acid molecules and proteins of the invention and pharmaceutical compositions for treating human cancer, viral infection, fungal infection, or parasitic infection.
REFERENCES:
patent: 4736866 (1988-04-01), Leder et al.
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4869903 (1989-09-01), Lifson et al.
patent: 5101025 (1992-03-01), Piatak, Jr. et al.
patent: 5128460 (1992-07-01), Piatak, Jr. et al.
patent: 6333303 (2001-12-01), Borgford
patent: 145111 (1985-06-01), None
patent: 171496 (1986-02-01), None
patent: 173494 (1986-05-01), None
patent: 239400 (1987-09-01), None
patent: 466222 (1992-01-01), None
patent: WO 86/01533 (1986-03-01), None
patent: WO 90/10457 (1990-09-01), None
patent: WO92/06193 (1992-04-01), None
patent: WO94/18332 (1994-08-01), None
patent: WO97/41233 (1997-11-01), None
Abad-Zapatero, C. et al.,Protein Sci.5:640-652 (1996).
Allured, V.S. et al.,Proc. Natl. Acad. Sci. USA83:1320-1324 (1986).
Amann et al.,Gene69:301-315 (1988).
Baldari. et al.,Embo J.6:229-234 (1987).
Bever Jr., C.T., Panitch, H.S., and Johnson, K.P. (1994) Neurology 44(4), 745-8.
Blackman, M.J. et al. (Mol. Biochem. Parasitol.62:103-114 (1995 or 1993?).
Blaha, I. et al.,FEBS Lett.309:389-393 (1992).
Blum, J.S. et al.,J. Biol. Chem.266: 22091-22095 (1991).
Bonifacino, J.S.,Nature384: 405-406 (1996).
Brinster et al.Proc. Natl. Acad. Sci. USA82:4438-4442 (1985).
Carvalho, K: et al.,Biochem. Biophys. Res. Comm.191:172-179 (1993).
Chang et al.,Nature275:615 (1978).
Chirgwin et al.,Biochemistry18, 5294-5299 (1979).
Cohen, P., Graves, H.C., Peehl, D.M., Kamarei, M., Giudice, L.C., and Rosenfeld, R.G. (1992) Journal of Clinal Endocrinology and Metabolism 75(4), 1046-53.
Cole et al., Monoclonal Antibodies in Cancer Therapy Allen R., Bliss, Inc., pp. 77-96 (1985).
Collier, R.J. & Kandel, J.,J. Biol. Chem.246:1496-1503 (1971).
Collier, R.J. et al.,J. Biol. Chem.257:5283-5285 (1982).
Columblatti, M. et al.,J. Biol. Chem.261:3030-3035 (1986).
Conover, C.A. and De Leon, D.D.,J. Biol. Chem.269(10), 7076-80 (1994).
Cook, J.P. et al.,Bioconjugate Chem.4, 440-447 (1993).
Cooper, J.A. and Bujard, H. (Mol. Biochem. Parasitol.56:151-160 (1992).
Cullen et al. (Bio/Technology5:369 (1987).
Cutfield, S.M. et al.,Biochemistry35:398-410 (1995).
Darke et al. (J. Biol. Chem.254:2307-2312 (1988).
Demeure, M.J. et al.,World J. Surg.16:770-776 (1992).
DiIannit, 1990, J. Biol. Chem. 285: 17345-17354 (1990).
Emmanuel, F. et al., Anal.Biochem.173: 134-141 (1988).
Endo, Y. & Tsurugi, K. J.,Biol. Chem.262:8128 (1987).
Fiani, M.L. et al.,Arch. Biochem. Biophys.307: 225-230 (1993).
Funmatsu et al.,Jap. J. Med. Sci. Biol.23:264-267 (1970).
Fusek, M. et al. (FEBS Lett.327:108-112 (1993).
Garred, O. et al. .(J. Biol. Chem.270:10817-10821 (1995).
Gluzman, Y. (1975) Cell, 23, 175-182).
Goldberg, D.E. et al. (J. Exp. Med.173:961-969 (1991).
Gray, G.L. et al.,Proc. Natl. Acad. Sci. USA81:2645-2649 (1984).
Greenfield, L. et al.,Proc. Natl. Acad. Sci. USA80:6853-6857 (1983).
Halling, K. et al.Nucleic Acids Res.13:8019 (1985).
Hammer et al.Nature315:680-683 (1985).
Hansen, G., Schuster, A., Zubrod, C., and Wahn, V. (1995) Respiration 62(3), 117-24.
Hinnen et al.,Proc. Natl. Acad. Sci. USA75:1929 (1978).
Hirowatari, Y. et al.,Arch. Virol.133:349-356 (1993).
Hirowatari, Y. et al.,Anal. Biochem.225:113-120 (1995).
Holmberg, K. and Myer, R.,Scand. J. Infect. Dis.18:179-192 (1986).
Honn, K.V. et al. (Biochem. Pharmacol.34:235-241 (1985).
Huse et al.,Science246:1275-1281 (1989).
Itoh et al.,J. Bacteriology153:163 (1983).
Jewell, D.A. et al.,Biochemistry31:7862-7869 (1992).
Kaufman et al.,EMBO J.6:187-195 (1987).
Kohler and Milstein (Nature256:495-497 (1975).
Kozbor et al.,Immunology Today4:7279 (1983).
Krane, S.M.,Ann. N.Y. Acad. Sci.732:1-10 (1994).
Kurjan and Herskowitz,Cell30:933-943 (1982).
Lamb and Lord,Eur. J. Biochem.14:265-270 (1985).
Leppla, S.H. et al. (Bacterial Protein Toxins zbl.bakt.suppl. 24:431-442 (1994).
Liu F. & Roizman, B. (J. Virol.65:5149-5156 (1991).
Long, A.C. et al.,FEBS Lett.258:75-78 (1989).
Lord, J.M.,Eur. J. Biochem.146:411-416 (1985).
Lord, J.M.,Eur. J. Biochem.146:403-409 (1985).
Lord, J.M. et al.,FASAB Journal8:201-208 (1994).
Lucklow, V.A., and Summers, M.D.,Virology170:31-39 (1989).
Mackay, A.R. et al.Lab. Invest.70:800-806 (1994).
May, M.J. et al. Embo. Journal, 8:301-308 at 302-303 (1989).
McCafferty et al.,Nature348:552-554 (1990).
McKerrow, J.H. et al.,J. Biol. Chem.260:3703-3707 (1985).
McPherson, R.A. et al. (Mol. Biochem. Parasitol.62:233-242 (1993).
Merrifield,J. Am. Chem. Assoc.85:2149-2154 (1964).
Messing, Meth in Enzymology 101:20-77, 1983.
Mikkelsen, T. et al.J. Neurosurge, 83:285-290 (1995).
Moore, D.H. et al.Gynecol. Oncol.65:78-82 (1997).
Morrison et al.,Proc. Natl Acad. Sci.U.S.A. 81:6851 (1985).
Muller, H.L., Oh, Y., Gargosky, S.E., Lehrnbecher, T., Hintz, R.L., and Rosenfeld, R.G. (1993) Journal of Clinical Endocrinology and Metabolism 77(5), 1113-9.
Nakano et al. (1995) J. of Neurosurgery 83(2), 298-307.
Nichols and Yanofsky, Meth in Enzymology 101:155, (1983).
Nwagwu, M. et al. (Exp. Parasitol.75:399-414 (1992).
O'Dea, K.P. et al.,Mol. Biochem. Parasitol.72:111-119 (1995).
O'Hare et al. (FEBS Lett.273:200-204 (1990).
Ogata, M. et al.,J. Biol. Chem.267:25396-25401 (1992).
Olsnes, S. & Phil, A. in Molecular action of toxins and viruses (eds. Cohen, P. & vanHeyningen, S.) 51-105 Elsevier Biomedical Press, Amsterdam, 1982).
Olson et al.,AIDS Res. and Human Retroviruses7:1025-1030 (1991).
Olsson et al.,Meth. Enzymol., 92:3-16 (1982).
Palmiter and BrinsterCell41:343-345 (1985).
Palmiter et al.Science222:809-814 (1983).
Panchal, R.G. et al.,Nature Biotechnology14:852-857 (1996).
Pastan et al.,Annals New York Academy of Sciences758:345-353 (1995).
Pastan, I. et al.,Annu. Rev. Biochem.61:331-354 (1992).
Peng, K-W, et al.Human Gene Therapy, 8:729-738 (1997).
Pettit, S.C. et al.,J. Biol. Chem.266:14539-14547 (1991).
Ray, T.L. and Payne, C.D. (Infect. Immunol.58:508-514 (1990).
Remold, H.H. et al. (Biochim. Biophys. Acta167:399-406 (1968).
Richardson, P.T. et al.,FEBS Lett.255:15-20 (1989).
Rosenthal, P.J. et al. (J. Clin. Invest.91:1052-1056 (1993).
Ruchel, R. et al,Zentralbl. Bakteriol. Mikrobiol Hyg. I Abt. Orig. A.255:537-548 (1983).
Russell et al., Gene 20: 231, (1982).
Rutenber, E. et al.Proteins10:240-250 (1991).
Sandvig, K. et al.,Biochem. Soc. Trans.21:707-711 (1993).
Sandvig, K. & van Deurs, B.,FEBS Lett.346: 99-102 (1994).
Scarborough, P.E. et al.,Protein Sci.2:264-276 (1993).
Schreiber, B, et al.,Diagn. Microbiol. Infect. Dis.3:1-5 (1985).
Schultz et al.,Gene54:113-123 (1987).
Schwartz, M.K.,Clin. Chim. Acta237:67-78 (1995).
Seed, B.,Nature329:840 (1987).
Shi, Y.E. et al.,Cancer Res.53:1409-1415 (1993).
Simmons et al.,Biol. Chem.261:7912 (1986).
Sinkar et al.,J. Biosci(Bangalore) 11:47-58 (1987).
Sloane, B.F. et al. (Proc. Natl. Acad. Sci. USA83:2483-2487 (1986).
Spiess, E. et al.,J. Histochem. Cytochem.42:917-929 (1994).
Spooner et al.,Mol. Immunol.31:117-125, (1994).
Takeda et al.,Nature314:452 (1985), Cabilly et al.
Teng et al.,Proc. Natl. Acad. Sci.U.S.A., 80:7308-7312 (1983).
Thompson, E.W. et al.,Breast Cancer Res. Treatment31:357-370 (1994).
Vasil, M.L. et al.,Infect. Immunol.16:353-361 (1977).
Vieira and Messing,Gene19:259-268 (1982).
Vitetta et al.,Science238:1098-1104(1987).
Vitetta & Thorpe,Seminars in Cell Biology2:47-58 (1991).
Vitetta et al.,Immunology Today14:252-259 (
Bereskin & Parr
Carlson Karen Cochrane
Gravelle Micheline
Twinstrand Therapeutics Inc.
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