Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1990-04-03
1992-03-17
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514867, 536103, A61K 31715, A61K 4740
Patent
active
050968947
ABSTRACT:
An improved oral rehydration solution comprising a mixture of rice dextrin and required electrolytes is provided. The functionality of the rice dextrin in oral rehydration solutions is superior to glucose in infants with chronic diarrhea resulting in lower stool output and enhanced water retention. Rice dextrin also has a polymer profile which provides more readily available glucose than corn dextrin or rice fluor. There is also provided a process for clarifying solutions of rice dextrin which involves a first filtration at 35.degree. C. and 50.degree. C. and a second filtration at temperatures above 80.degree. C. using filter aid and activated carbon.
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Lebenthal et al., J. Pediatrics, 103:29-34 (1983).
Carpenter et al., New England Journal of Medicine, 319:1346-1348 (1988).
Patra et al., Archives of Disease in Childhood, 57:910-912 (1982).
Molla, et al., The Lancet, 1317-1319 (1982).
El Mougi et al., Journal of Pediatric Gastroenterology and Nutrition, 7:572-576 (1988).
Molla et al., Journal of Pediatric Gastroenterology and Nutrition, 8:81-84 (1989).
Akrabawi Salim S.
Euber John R.
Litov Richard E.
Moran J. Roberto
Tao Michael C.
Bristol--Myers Squibb Company
Griffin Ronald W.
Uloth Robert H.
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