Ribozymes targeting the MoMLV PSI packaging sequence and the HIV

Details Ribozymes targeting the MoMLV PSI packaging sequence and the HIV Ribozymes targeting the MoMLV PSI packaging sequence and the HIV

1994-09-21

2000-09-05

Schwartzman, Robert A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435325, 435366, C12N 510

Patent

active

061141674

ABSTRACT:
A cell comprising a synthetic non-naturally occurring oligonucleotide compound comprises nucleotides whose sequence defines a conserved catalytic region and nucleotides whose sequence hybridizes with a predetermined target sequence within a MoMLV Psi packaging sequence on the HIV tat sequence. The catalytic region may be derived from a hammerhead ribozyme, a hairpin ribozyme a hepatitis delta ribozyme, an PNAase P ribozyme, a group I intron or a group II intron.

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