Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1995-05-04
1997-04-01
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435 6, 435 9131, 4351721, 4351723, 4353201, 435325, 435364, 435367, 536 231, 536 232, 536 245, 514 44, C07H 2104, A61K 4800, C12N 1585
Patent
active
056164904
ABSTRACT:
An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of an inflammatory disease.
REFERENCES:
patent: 4987071 (1991-01-01), Cech
patent: 5168053 (1990-08-01), Altman et al.
Baringa, "Ribozymes: Killing the Messenger," Science 262:1521-1514 (1993).
Cech, "Ribozymes and Their Medical Implications" JAMA 260:3030-3034 (1988).
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme," Cell 35:849-857 (1983).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence," Biochemistry 28:4929-4933 (1989).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA", Nucleic Acids Research 18:299-304 (1990).
Hampel et al., Nucleic Acids Research 18:299 (1990).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585-591 (1988).
Hession et al., WO 9013300 (Nov. 15, 1990) provided as CA Abstr. Acc# 114(25): 292037g.
Johnston and Hoth, "Present Status and Future Prospects for HIV Therapies," Science 260:1286-1293 (1993).
Kim et al., Proc. Natl. Acad. Sci. USA 84:788 (1987).
Mamone et al., "Design of Hammerhead Ribozymes Targeted to Sequences in HIV, HSV and the RAT ANF Gene," Abstract of Keystone, CO (May 27, 1992).
Pavco et al., "Regulation of Self-Splicing Reactions by Antisense RNA," Abstract of Keystone, CO (May 27, 1992).
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence," Biochemistry 31:16-21 (1992).
Rossi et al, "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," Aids Research and Human Retroviruses 8:183 (1992).
Rossi et al., "Ribozyme Mediated Intracellular Immunity to HIV-1 in CD4," J. Cell Biochem. Suppl 14A:D428 (1990).
Sarver et al., "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" Science 247:1222-1225 (1990).
Sioud et al., J. Mol. Biol. 223:831-835 (1992).
Tanabe et al., J. Biol. Chem. 262:16580 (1987), provided as BIOSIS Abstr. 85047487.
Weerasinghe et al., "Resistance to Human Immunodeficiency Virus Type 1 (HIV-1) Infection in Human CD4.sup.+ Lymphocyte-Derived Cell Lines Conferred by Using Retroviral Vectors Expressing an HIV-1 RNA-Specific Ribozyme," Journal of Virology 65:5531-4 (1994).
Draper Kenneth G.
Sullivan Sean M.
LeGuyader John L.
Ribozyme Pharmaceuticals Inc.
LandOfFree
Ribozymes targeted to TNF-.alpha. RNA does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ribozymes targeted to TNF-.alpha. RNA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ribozymes targeted to TNF-.alpha. RNA will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-538357