Ribozymes targeted to human IL-15 mRNA

Details Ribozymes targeted to human IL-15 mRNA Ribozymes targeted to human IL-15 mRNA

1997-10-31

2000-07-11

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 9131, 4353201, 435325, 435366, 435455, 536 231, 536 232, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1500

Patent

active

060871725

ABSTRACT:
Enzymatic RNA molecules which cleave mRNA encoding IL-15, are provided. The constructs of the invention include regulatory regions for expression in cells, cell lines, or transgenic non-human animals. The ribozymes of the invention are directed against IL-15 mRNA and are useful in treating rheumatoid arthritis.

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