Ribozymes targeted to apo(a) mRNA

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se

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435 6, 435 9131, 4351723, 4353201, 435325, 536 231, 536 232, 536 245, 514 44, C12N 1585, C12Q 168, C07H 2104

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055997066

ABSTRACT:
Enzymatic RNA molecules which cleave apo(a) mRNA.

REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
Symons, "Ribozymes," Current Opinion in Structural Biology 4(3):322-330 (1994).
Stull et al. Pharm. Res. 12: 465 (1995).
Berg, "A New Serum Type System in Man--the Lp System," Acta Pathol. Microbiol. Scand. 59:369-382 (1963).
Chen et al., "Multitarget-Ribozyme Directed to Cleave at up toNine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1Replication-Potential Effectiveness Against Most PresentlySequenced HIV-1 Isolates," Nucleic Acids Research 20:4581-4589(1992).
Chowrira and Burke, "Extensive Phosphorothioate Substitution Yields Highly Active and Nuclease-Resistant Hairpin Ribozymes," Nucleic Acids Res. 20:2835-2840 (1992).
Collins and Olive, "Reaction Conditions and Kinetics of Self-Cleavage of a Ribozyme Derived From Neurospora VS RNA," Biochemistry 32:2795-2799 (1993).
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodeficiency Virus Type I Expression," Journal of Virology 66:1432-1441 (1992).
Elroy-Stein and Moss, "Cytoplasmic Expression System Based on Constitutive Synthesis of Bacteriophage T7 RNA Polymerase in Mammalian Cells," Proc. Natl. Acad. Sci. USA 87:6743-6747 (1990).
Friedman, "Progress Toward Human Gene Therapy," Science 244:1275-1281 (1989).
Gao and Huang, "Cytoplasmic Expression of a Reporter Gene by Co-Delivery of T7 RNA Polymerase and T7 Promoter Sequence with Cationic Liposomes," Nucleic Acids Res. 21:2867-2872 (1993).
Gonzalez-Gronow et al., "Further Characterization of the Cellular Plasminogen Binding Site: Evidence that Plasminogen 2 and Lipoprotein a Compete for the Same Site," Biochemistry 28:2374-2377 (1989).
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme," Cell 35:849-857 (1983).
Gurakar et al., "Levels of Lipoprotein Lp(a) Decline with Neomycin and Niacin Treatment," Atherosclerosis 57:293-301 (1985).
Hajjar et al., "Lipoportein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis," Nature 339:303-305 (1989).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA," Nucleic Acids Research 18:299-304 (1990).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence," Biochemistry 28:4929-4933 (1989).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585-591 (1988).
Hertel et al., "Numbering System for the Hammerhead," Nucleic Acids Res. 20:3252 (1992).
Jaeger et al., "Improved Predictions of Secondary Structures for RNA," Proc. Natl. Acad. Sci. USA 86:7706-7710 (1989).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1989).
Kashani-Sabet et al., "Reversal of the Malignant Phenotype by an Anti-ras Ribozyme," Antisense Research & Development 2:3-15 (1992).
L'Huillier et al., "Cytoplasmic Delivery of Ribozymes Leads to Efficient Reduction in .alpha.-Lactalbumin mRNA Levels in C1271 Mouse," Embo J. 11:4411-4418 (1992).
Lawn et al., "Atherogenesis in transgenic mice expressing human apolipoprotein(a)," Nature 360:670-672 (1992).
Leren et al., "Effects of lovastatin alone and in combination with cholestyramine on serum lipids and apolipoproteins in heterozygotes for familial hypercholesterolemia," Atherosclerosis 73:135-141 (1988).
Lieber et al., "Stable High-Level Gene Expression in Mammalian Cells by T7 Phage RNA Polymerase," Methods Enzymol. 217:47-66 (1993).
Lisziewicz et al., "Inhibition of Human Immunodeficiency Virus Type 1 Replication by Regulated Expression of a Polymeric Tat Activation Response RNA Decoy as a Strategy for Gene Therapy in AIDS," Proc. Natl. Acad. Aci. U.S.A. 90:8000-8004 (1993).
McLean et al., "cDNA sequence of human apolipoprotein(a) is homologous to plasminogen," Nature 330:132-137 (1987).
Miles et al., "A potential basis for the thrombotic risks associated with lipoprotein(a)," Nature 339:301-303 (1989).
Moliterno et al., "Relation of Plasma Lipoprotein(a) to Infarct Artery Patency in Survivors of Myocardial Infarction," Circulation 88:935-940 (1993).
Ohkawa et al., "Activities of HIV-RNA Targeted Ribozymes Transcribed From a `Shot-Gun` Type Ribozyme-trimming Plasmid," Nucleic Acids Symp. Ser. 27:15-16 (1992).
Ojwang et al., "Inhibition of Human Immunodeficiency Virus Type 1Expression by a Hairpin Ribozyme," Proc. Natl. Acad. Sci. USA 89:10802-10806 (1992).
Perreault et al., "Mixed Deoxyribo- and Ribo-Oligonucleotides with Catalytic Activity," Nature 344:565-567 (1990).
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence," Biochemistry 31:16-21 (1992).
Pieken et al., "Kinetic Characterization of Ribonucleasep-Resistant 2'-Modified Hammerhead Ribozymes," Science 253:314-317 (1991).
Roemer and Friedman, "Concepts and strategies for human gene therapy," Eur. J. Biochem. 208:211-225 (1992).
Rossi et al, "Ribozymes as Anti-HIV-1 Therapeutic Agents: Principles, Applications, and Problems," Aids Research and Human Retroviruses 8:183-189 (1992).
Rubino et al., "Nucleotide sequence4 and structural analysis of two satellite RNAs associated with chicory yellow mottle virus," Journal of General Virology 71:1897-1903 (1990).
Sarver et al., "Catalytic RNAs (Ribozymes): A New Frontier in Biomedical Applications," AIDS Res. Revs. 2:259 (1992).
Saville and Collins, "A Site-Specific Self-Cleavage Reaction Performed by a Novel RNA In Neurospora Mitochondria," Cell 61:685-696 (1990).
Saville and Collins, "RNA-Mediated Ligation of Self-Cleavage Products of a Neurospora Mitochondrial Plasmid Transcript," Proc. Natl. Acad. Sci. USA 88:8826-8830 (1991).
Scanlon et al., "Ribozyme.varies.Mediated Cleavage of c-fos mRNA Reduces Gene Expression of DNA Synthesis Enzymes and Metallothionein," Proc. Natl. Acad. Sci. USA 88:10591-10595 (1991).
Scanu et al., "Lipoprotein(a) and Atherosclerosis," Annals of Internal Medicine 115:209-218 (1991).
Scaringe et al., "Chemical synthesis of biologically active oligoribonucleotides using .beta.-cyanoethyl protected ribonucleoside phosphoramidites," Nucl Acids Res. 18:5433-5441 (1990).
Scott, "Lipoprotein(a): Thrombotic and atherogenic," BMJ 303:663-664 (1991).
Taira et al., "Construction of a novel RNA-transcript-trimming plasmid which can be used both in vitro in place of run-off and (G)-free transcriptions and in vivo as multi-sequences transcription vectors," Nucleic Acids Research 19:5125-5130 (1991).
Textbook of Medical Physiology, Guton, A. C., Saunders Company, Philadelphia pp. 761-764 (1991).
Tomlinson, "Rhesus Monkey Apoliporprotein(a)," J. Biol. Chem. 264:5957-5956 (1989).
Uhlenbeck, "A Small Catalytic Oligoribonucleotide," Nature 328:596-600 (1987).
Usman et al., "Automated Chemical Synthesis of Long Oligoribonucleotides Using 2'-O-Silylated Ribonucleoside 3'-O-Phosphoramidites on a Controlled-Pore Glass Support: Synthesis of a 43-Nucleotide Seqeunce Similar to the 3'-Half Molecule of an Escherichia coli Formylmethoionine tRNA," J. Am. Chem. Soc. 109:7845-7854 (1987).
Usman and Cedergren, "Exploiting the chemical synthesis of RNA," TIBS 17:334-339 (1992).
Uterman, "The Mysteries of Lipoprotein(a)," Science 246:904-910 (1989).
Ventura et al., "Activation of HIV-Specific Ribozyme Activity by Self-Cleavage," Nucleic Acids Research 21:3249-3255 (1993).
Weerasinghe et al., "Resistance to Human Immunodeficiency Virus Type1 (HIV-1) Infection in Human CD4.sup.+ Lymphocyte-Derived Cell Lines Conferred by Using Retroviral Vectors Expressing an HIV-1 RNA-Specific Ribozyme," Journal of Virology 65:5531-5534 (1994).
Williams et al., "Occlusive Arterial Thrombosis in Cynomolgus Monkeys with Varying Plasma Concentrations of Lipoprotein(a)," Atheroscler. Thromb. 13:548-554 (1993).
Woolf et al., "Specificity of Antisense Oligonucleotides in vivo," Proc. Natl. Acad. Sci. USA 89:7305-7309 (1992).
Yu et al., "A Hairpin Ribozyme Inhibits Expression of Diverse Strains of Human Immunodeficiency Virus Type 1," Proc. Natl. Acad. Sci.

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