Ribozymes

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 231, 4351723, 4352401, 4352523, 4353201, C12N 1511, C12N 1570, C12N 1574, C12N 1579

Patent

active

052546780

ABSTRACT:
Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.

REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
Uhlenbeck et al., (1987), Nature, vol. 328, pp. 596-600.
Forster et al., (Jul. 1987), Cell, vol. 50, pp. 9-16.
McClain et al., (1987), Science, vol. 238, pp. 527-530.
Sampson et al., (1987), Cold Spring Harbor Sym. Quant. Biol., vol. 52, pp. 267-275.
Perriman et al., Gene, 113:157 (1992).
Boehm, S., (1987), "Similarities Between a Predicted Secondary Structure for the M1 RNA Ribozyme and the tRNA Binding Center of the 16S rRNA from E. coli", FEBS Letters, 220: 283-287 (Exhibit 1).
Bruening, G., (1987), "Compilation of Self-Cleaving Sequences from Plant Virus Satellite RNAs and Other Sources", Methods in Enzymology, 180: 546-558 (Exhibit 2).
Cech, T. R., (1987), "The Chemical of Self-Solicing RNA Enzymes", Science, 236: 1532-1539, (Exhibit 3).
Chuat, J. et al., (1989), "Can Ribozymes be Used to Regulate Procaryote Gene Expression?", Biochemical and Biophysical Research Communications, 162: 1025-1029 (Exhibit 4).
Cotten, M. et al., (1989), "Ribozyme Medicated Destruction of RNA in vivo", The EMBO Journal, 8: 3861-3866 (Exhibit 5).
Eckner, R. et al., (1991), "Mature mRNA 3'End Formation Simulates RNA Export from the Nucleus", The EMBO Journal, 10: 3513-3522 (Exhibit 6).
Forster, A. C. et al., (1988), "Self-Cleaving Viroid and Newt RNAs May Only Be Active As Dimers", Nature, 334: 265-267 (Exhibit 7).
Forster, A. C. and Symons, R. H., (1987), "Self-Cleavage of Plus and Minus RNAs of a Virusoid and a Structural Model for Active Sites", Cell, 49: 211-220 (Exhibit 8).
Haseloff, J. and W. L. Gerlach, (1988), "Simple RNA enzyme with new and highly specific endoribonuclease activities", Nature, 334: 585-591 (Exhibit 9).
Huillier, A. et al., Ribozyme Mediated Suppression of Lactalbumin Expressed in C1271 Cells by T7/Vaccinia Virus, (Abstract from conference proceedings), (Exhibit 10).
Hutchins, C. J. et al., (1986), "Self-Cleavage of Plus and Minus RNA Transcripts of Avocaob Sunblotch Virus", Nucleic Acids Research, 14: 3627-3635 (Exhibit 11).
Kikuchi, Y. et al., (1991), "Site-Specific Cleavage of Natural mRNA Sequences by Newly Designed Hairpin Catalytic RNAs", Nucleic Acids Research, 19: 6751-6755 (Exhibit 12).
Koizumi et al., (1988), "Construction of a Series of Several Self-Cleaving RNA Duplexes Using Synthetic 21-mers", FEBS Letters, 228, No. 2, 228-230; (Exhibit 13).
Koizumi et al., (1989), "Design of RNA Enzymes Distinguishing a Single Base Mutation in RNA", Nucleic Acids Research, 17: 7059-7071 (Exhibit 14).
Lamb, J. W. & Hay, R. T., (1990), "Ribozymes that Cleave Potato Leafroll Virus RNA with the Coat Protein and Polymerase Genes", J. Gen. Virol., 71: 2257-2264 (Exhibit 15).
Miller, W. A. et al., (1991), "A Satellite RNA of Barley Yellow Dwarf Virus Contains a Novel Hammerhead Structure in the Self-cleavage Domain", Virology, 183: 711-720 (Exhibit 16).
Ruffner, D. E. et al., (1989), "Studies on the Hammerhead RNA Self-Cleaving domain", Gene, 82: 31-41 (Exhibit 17).
Ruffner, D. E. et al., (1990), "Sequence Requirements of the Hammerhead RNA Self-Cleaving Reaction", Biochemistry, 29: 10695-10702 (Exhibit 18).
Sarver, N. et al., (1990), "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents", Science, 247: 1222-1224 (Exhibit 19).
Saxena, S. et al., (1990), "Ribozymes Correctly Cleave a Model Substrate and Endogenous RNA in vivo", J. Biol. Chem., 265: 17106-17109 (Exhibit 20).
Scanlon, K. et al., (1991), "Ribozyme-Medicated Cleavage of c-fos RNA Reduces Gene Expression of DNA Synthesis Enzymes and Metallothionein", Proc. Natl. Acad. Sci. USA, 88: 10591-10595 (Exhibit 21).
Sheldon, C. C. & Symons, R. H., (1989), "RNA Stem Stability in the Formation of a Self-Cleaving Hammerhead Structure", Nucleic Acids Research, 17: 5665-5678 (Exhibit 22).
Sheldon, C. C. & Symons, R. H., (1989), "Mutagenesis Analysis of a Self-Cleaving RNA", Nucleic Acids Research, 17: 5679-5686 (Exhibit 23).
Symons, R. H., (1989), "Self-Cleavage of RNA in the Replication of Small Pathogens of Plants and Animals", Tibs, 14: 445-450 (Exhibit 24).
Tabler, M. & Tsagris, M., (1991), "Catalytic Antisense RNAs Produced by Incorporating Ribozymes Cassettes into cDNA", Gene, 108: 175-183 (Exhibit 25).
Zaug, A. J. & Cech, T. R., (1986), "The Tetrahymena Ribozyme Acts like an RNA Restriction Endonuclease", Science, 231: 473-474 (Exhibit 26).
Zaug, A. J. et al., (1986), "The Tetrahymena Ribozyme Acts like an RNA Restriction Endonuclease", Nature, 324: 429-433 (Exhibit 27).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Ribozymes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ribozymes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ribozymes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1352778

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.