Ribozyme-mediated inhibition of bovine leukemia virus

Details Ribozyme-mediated inhibition of bovine leukemia virus Ribozyme-mediated inhibition of bovine leukemia virus

1995-08-28

1997-04-01

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 9131, 4351723, 4353201, 536 231, 536 232, 536 245, 514 44, C12Q 168, C12N 1585, C07H 2104, A61K 4800

Patent

active

056164661

ABSTRACT:
A ribozyme is provided which is capable of cleaving bovine leukemia virus (BLV) RNA both in a cell free system and intracellularly. The ribozyme of the present invention comprises the hammerhead motif flanked by antisense sequences complementary to BLV rex/tax RNA. Introduction of the ribozyme into BLV-infected cells results in inhibition of BLV protein expression, allowing for the control of BLV infection.

REFERENCES:
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