Ribozyme compositions and methods for use

Details Ribozyme compositions and methods for use Ribozyme compositions and methods for use

1989-09-25

1993-07-06

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 6, 435 5, 536 27, 536 231, 935 77, 935 78, C12P 1934, C12Q 168, C07H 1512, C12N 1500

Patent

active

052253376

ABSTRACT:
Ribozymes, sequences cleaving RNA, derived from sequences present in the hepatitis delta virus, have been engineered for greater specificity without increasing size. The specific ribozyme sequences are useful as reagents for cleaving RNA for experimental studies as well as antiviral therapies. Examples demonstrating the targeting of these sequences against HIV and Crohn's disease are described in detail. The sequences are also useful as diagnostics for the detection of hepatitis delta virus in tissue and fluid samples, as in blood banking, as well as in isolation and characterization of new viroids having ribozyme activity, using an RNA-specific hybridization method. Based on analysis of the two domain structure of the hepatitis delta virus, it is possible to construct a vector for expression of non-hepatitis delta virus proteins in mammalian cells.

REFERENCES:
patent: 4795700 (1989-01-01), Dervan et al.
patent: 4888278 (1989-12-01), Singer et al.
Young et al, Nature, vol. 343, Jan. 4 1990, p. 28.
Bergmann et al, in "Self-cleaving RNA as an Anti-HIV Agent:Design and Delivery to Cells", NIAID, to Jun. 21-23, 1989, p. 24.
Wu et al, Proc. Natl. Acad. Sci. USA, vol. 86, Mar. 1989, pp. 1831-1835.
Wu and Lai, Science 243, 652-654 (Feb. 3, 1989).
Wu, et al., Proc. Natl. Acad. Sci. USA 86, 1831-1835 (Mar. 1989).
Branch, et al., Science 243, 649-652 (Feb. 3, 1989).
Wu, et al., Proc. Natl. Acad. USA 86, 1831-1835 (Mar. 1989).
Waugh, et al., Science 244, 1569-1571 (Jun. 1989).
Doudna and Szostak, Nature 339, 519-522 (Jun. 1989).
Cech, Nature 339, 507-508 (Jun. 1989).
Latham and Cech, Science 245, 276-282 (Jul. 1989).
"Self-Cleaving RNA as an Anti-HIV Agent: Design and Delivery to Cells" (Development Therapeutics Branch AIDS Program, National Institute of Allergy and Infectious Diseases Jun. 21-23, 1989).
Maddox, Nature 342, 409-413 (Dec. 1989).
Young, et al., Nature 343, 28 (Jan. 1990).
Papas, Oncogenesis and AIDS (Greece, 1989).
Cech, Robert A. Welch Foundation Conferences on Chemical Research, pp. 345-355 (Nov. 4-6, 1985).
Reed, et al., Cell 30, 627-636 (1982).
Guerrier-Takada, et al., Cell 45, 177-183 (1986).
McClain, et al., Science 238, 527-528 (1987).
Altman, et al., Gene 82, 63-64 (1989).
Guerrier-Takada, et al., Science 246, 1578-1584 (1989).
Baer, et al., Nucleic Acids Research 18 (1), 97-103 (1989 or 1990).
Lee, et al., Mol. Cell. Biol. 9(6), 2536-2543 (Jun. 1989).
Pace, et al., Gene 82, 65-75 (1989).
Pace, et al., J. Biol. Chem. 265(7), 3587-3590 (1990).
Altman, Advances in Enzymology A. Meister, ed., vol. 62, pp. 1-36, John Wiley & Sons, 1989.
Uhlenbeck, Nature 328, 596-600 (1987).
Kruger, et al., Cell 31, 147-157 (1982).
Zaug, et al., Nature 301, 578-583 (1983).
Zaug, et al., Science 224, 574-578 (1984).
Sullivan, et al., Cell 42, 639-648 (1985).
Been, et al., Cell 47, 207-216 (1986).
Inoue, et al., J. Mol. Biol. 189, 143-165 (1986).
Zaug, et al., Science 231, 470-475 (1986).
Surratt, et al., Molecular Biology of RNA 79-88 (Alan R. Liss, Inc., 1989).
Bonino, et al., J. Virology 58(3), 945-950 (Jun. 1986).
Prody, et al., Science 231, 1577-1580 (Mar. 1986).
Wang, et al., Nature 323, 508-514 (Oct. 1986).
Kos; et al., Nature 323, 558-560 (Oct. 1986).
Chen, et al., Proc. Natl. Acad. Sci. USA 83, 8774-8778 (Nov. 1986).
Zaug, et al., Nature 324, 429-433 (Dec. 1986).
Joyce, et al., Proc. Natl. Acad. Sci. USA 84, 4398-4402 (Jul. 1987).
Darnell, Scientific American.
Taylor, et al., J. Virology 61(9), 2891-2895 (Sep. 1987).
Joyce and Inoue, Nucleic Acids Res. 15, 9825-9840 (1987).
Kay and Inoue, Nucleic Acids Res. 15, 1559-1577 (1987).
Pechan, et al., Z. Naturforsch. 42c, 1006-1008 (1987).
Kim and Cech, Proc. Natl. Acad. Sci. USA 84, 8788-8792 (Dec. 1987).
Hadid, Molecular Plant Pathology 78(5), 575-578 (1988).
Salazar, et al., J. gen. Virol. 69, 879-889 (1988).
Been and Cech, Science 239, 112-1416 (Mar. 1988).
Abouhaidar and Paliwal, J. gen. Virol. 69, 2369-2373 (1988).
Kuo, et al., J. Virology 2(6), 1855-1861 (Jun. 1988).
Negro, et al., J. Infectious Diseases 158(1), 151 (Jul. 1988).
Zaug, et al., Biochemistry 27, 8924-8931 (1988).
Haseloff & Gerlach, Nature 334, 585-591 (Aug. 1988).
Baltimore, Nature 335, 395-396 (Sep. 1988).
Cech, Jama 260(20), 3030-3034 (Nov. 1988).
Taira, et al., Nucleic Acids Research 17(10), 3699-3708 (1989).
Wu and Lai, Science 243, 652-654 (Feb. 1989).
Ruden and Gilboa, J. Virol. 63(2), 677-682 (Feb. 1989).

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