Ribozyme cleavage of HIV RNA

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se

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435 6, 435 9131, 4353201, 435325, 435366, 435375, 536 231, 536 232, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1500, C12N 1585

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060690070

ABSTRACT:
Ribozymes useful to cleave HIV-1 and other viral or endogenous cellular RNAs are disclosed. Also disclosed are transformed cells which express such ribozymes and human AIDS therapy involving the administration of such ribozymes.

REFERENCES:
Barinaga Science 262: 1512-1514 (1993).
Johnston et al. Science 260: 1286-1293 (1993).
Gerlach et al. J. Cell. Biochem. Suppl. 12C, 239, 1988.
Rossi et al. J. Cell. Biochem. Suppl. 13B, G329, 1989.

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