Ribotoxin conjugates

Details Ribotoxin conjugates Ribotoxin conjugates

1987-12-11

1990-10-09

Draper, Garnette

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530370, 530377, 530387, 530388, 530390, 530402, 530403, 530404, 530405, 530406, 530408, 530409, 530410, 530411, 424 8591, 514885, A61K 3702, A61K 3900, C07K 1528

Patent

active

049621890

ABSTRACT:
The invention herein is directed to methods using Procion dyes to perform separations of interest in manipulating the NAD.sup.+ -independent ribotoxins. The methods are useful for preparing therapeutic agents containing these ribotoxins or their A polypeptide components. This separation method has been applied in particular to preparing hybrid toxins containing ricin toxins, both for purifying the resulting products and also for separating the components intended to be used in the preparation of these end products. In addition, a novel ricin isotoxin prepared using the method of the invention is disclosed.

REFERENCES:
patent: 4771128 (1988-09-01), Ferris et al.
Funatsu et al., Agric. Biol. Chem. 42, 1978, pp. 851-859.
Mise et al., Agric. Biol. Chem. 41(10) 1977, pp. 2041-2046.
Middlebrook et al., Microbiol. Rev. 48(3) 1984, pp. 199-221.
Olsnes et al., Pharma. Ther. vol. 15, 1982, pp. 355-381.
Appukuttan et al., Biochimica et Biophysica Acta, 580: 10-14 (1979).

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