Ribosome-inactivating glycoproteins, modified by oxidation of th

Details Ribosome-inactivating glycoproteins, modified by oxidation of th Ribosome-inactivating glycoproteins, modified by oxidation of th

1989-09-08

1992-04-14

Nucker, Christine

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530395, 530397, 530863, 424 8591, C07K 1702, C07K 1528, A61K 3944

Patent

active

051049767

ABSTRACT:
Glycoprotein which inactivates ribosomes (GPIR) the ribosome-inhibiting activity of the native GPIR and having a prolonged-action in vivo which is obtained by oxidation of its osidic units by the action of periodate ions, and simultaneous blocking of the oxidation product by formation of a Schiff's base with a suitable primary amine. Said modified glycoprotein may be coupled to an antibody or a fragment thereof in order to form an immunotoxin.

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Wawrzynczak et al. in Immunoconjugates. Antibody Conjugates in Radioimaging and Therapy of Cancer, (C. W. Vogel ed) New York, Oxford Univ. Press pp. 28-55.
Brown et al (1978) Arch. Biochem. Biophys. 188:418-428.
Olsnes et al. (1982) Pharmac. Ther. 15:355-381.
Blair et al (1983) J. Immunol. Methods 59:129-143.
Murayama et al (1978) Immunochem. 15:523-528.
Skilleter et al (1985) Biochim. Biophys. Acta 842:12-21.
Vitetta et al (1985) Cancer Drug Delivery 2(3):191-198.

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