Ribosome-inactivating glycoproteins, modified by oxidation of th

Details Ribosome-inactivating glycoproteins, modified by oxidation of th Ribosome-inactivating glycoproteins, modified by oxidation of th

1986-12-15

1990-03-27

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 858, 514 8, 530371, 530377, 530391, 530395, 530396, 530410, 530370, 530372, A61K 3944, A61K 4505, C07K 1514

Patent

active

049119117

ABSTRACT:
Glycoprotein (GPIR) the ribosome-inhibiting activity of the native GPIR and having a prolongedaction in vivo which is obtained by oxidation of its osidic units by the action of periodate ions, and simultaneous blocking of the oxidation product by formation of a Schiff's base with a suitable primary amine. Said modified glycoprotein may be coupled to an antibody or a fragment thereof in order to form an immunotoxin.

REFERENCES:
patent: 4093607 (1978-06-01), Sela et al.
patent: 4154726 (1979-05-01), Kajinami
patent: 4340535 (1982-07-01), Voisin et al.
patent: 4356170 (1982-10-01), Jennings et al.
patent: 4368149 (1983-01-01), Masliho et al.
patent: 4419444 (1983-12-01), Quastt
patent: 4590071 (1986-05-01), Scannon et al.
patent: 4689401 (1987-08-01), Ferris
Chemical Abstracts, vol. 88, No. 25, 19 Jun. 1978, p. 213, No. 1184277s, Columbus, Ohio, U.S.; K. Sandvig et al: "Chemical modifications of the toxic lectins abrin and ricin," & EUR. J. Biochem. 1978, 84(2), 323-31.
EUR. J. Biochem. 116, 447-454 (1981), Thorpe et al.
Immunochemistry, 15, 523-528 (1978), Murayama et al.
Biochmica et Biophysica Acta(1), 842(1), 12-21 (1985), Skilleter et al.

Affiliated with

Also associated with

Rating

Ribosome-inactivating glycoproteins, modified by oxidation of th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ribosome-inactivating glycoproteins, modified by oxidation of th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ribosome-inactivating glycoproteins, modified by oxidation of th will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1649638