Ribosome-inactivating glycoproteins, modified by oxidation of th

Details Ribosome-inactivating glycoproteins, modified by oxidation of th Ribosome-inactivating glycoproteins, modified by oxidation of th

1989-09-08

1992-04-21

Nucker, Christine

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530395, 530397, 530866, 530863, 424 8591, C07K 1702, C07K 1528, A61K 3944

Patent

active

051069563

ABSTRACT:
Glycoprotein which inactivates ribosomes (GPIR) having the ribosome-inhibiting activity of the native GPIR and having a prolonged-action in vivo which is obtained by oxidation of its osidic units by the action of periodate ions, and simultaneous reduction with cyanoborohydride ions. Said modified glycoprotein may be coupled to an antibody or a fragment thereof in order to form an immunotoxin having a prolonged-action in vivo.

REFERENCES:
patent: 4340535 (1982-07-01), Voisin et al.
patent: 4368149 (1983-01-01), Masuho et al.
patent: 4911911 (1990-03-01), Casellas et al.
patent: 4911912 (1990-03-01), Casellas et al.
Blair et al., (1983), J. Immunol. Methods 59:129-143.
Skilleter et al. (1985), Biochim. Biophys. Acta 842:12-21.
Vitetta et al., (1985) Cancer Drug Delivery 2:191-198.
Wawrzynczak et al. (1987) in Immunoconjugates Antibody Conjugates in Radioimaging and Therapy of Cancer (C-W Vogel, ed), N.Y., Oxford Univ. Press. pp. 28-55.
Olsnes et al., (1982), Pharmac. Ther. 15:355-381.

Affiliated with

Also associated with

Rating

Ribosome-inactivating glycoproteins, modified by oxidation of th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ribosome-inactivating glycoproteins, modified by oxidation of th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ribosome-inactivating glycoproteins, modified by oxidation of th will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1587605