Ribosomal inhibiting protein-immunoglobulin conjugates with spec

Details Ribosomal inhibiting protein-immunoglobulin conjugates with spec Ribosomal inhibiting protein-immunoglobulin conjugates with spec

1988-06-08

1990-04-10

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530387, 530389, 530806, 530808, 530828, 43524027, 4351722, 424 8591, 424 858, A61K 39395, C12N 1500, C07K 1514

Patent

active

049162136

ABSTRACT:
Novel compositions and methods are provided for the treatment of cancer employing monoclonal antibodies (MoAbs) conjugated to a toxin. According to the present invention, MoAbs defining epitopes on either a tumor associated glycoprotein antigen of about 72 kD m.w. or on carcinoembryonic antigen conjugated to a ribosomal inhibiting protein, or the like, are employed either alone or in combination as cytotoxic agents in the treatment of various cancers including, but not limited to, colorectal carcinoma, ovarian carcinoma and osteogenic sarcoma.
Hydridomas XMMCO-791 and XMMCO-228 were deposited with the A.T.C.C. on Aug. 14, 1986 and given A.T.C.C. Accession Nos. HB 9173 and HB 9174, respectively.

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