Ribonucleotide reductase inhibitors

Details Ribonucleotide reductase inhibitors Ribonucleotide reductase inhibitors

1990-02-01

1991-12-10

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 17, 514 18, 514 19, 530326, 530327, 530328, 530329, C07K 700, C07K 708, A61K 3702

Patent

active

050718355

ABSTRACT:
Disclosed herein are peptides of the formula

REFERENCES:
patent: 4448730 (1984-05-01), van't Riet
patent: 4795740 (1989-01-01), Cohen et al.
patent: 4814432 (1989-03-01), Freidinger et al.
patent: 4837304 (1989-06-01), Garskey et al.
patent: 4845195 (1989-07-01), Colonno et al.
Thelander et al., Molecular and Cellular Biology, vol. 6, No. 10, 1986, pp. 3433-3442.
van't Reit et al., "Synthesis of Hydroxy-and Amino-Substituted Benzohydroxamic Acids: Inhibition of Ribonucleotide Reductase and Antitumor Activity", J. Med. Chem. 22 (5):589 (1979).
Takeda et al., "Role Ribonucleotide Reductase in Expression of the Neoplastic Program", Life Sciences 28:1007 (1981).
Weber et al., "Dynamics of Modulation of Biochemical Programs in Cancer Cells", Adv. Enz. Reg. 19:87 (1981).
Cory et al., "Specific Inhibition of Subunits of Ribonucleotide Reductase as a New Approach to Combination Chemotherapy", Adv. Enz. Reg. 19:139 (1981).

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