Ri fusion antigen recognized by antibodies associated with paran

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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4241851, 4242771, 435 71, 435 697, 435 79, 436 64, 436536, 436542, 530350, 530403, 530828, G01N 33579, C07K 1447, C07K 1900, C07K 14705

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active

056143710

ABSTRACT:
An isolated nucleic acid sequence encoding Ri paraneoplastic antigenic polypeptide is provided by this invention. This invention also provides a purified Ri antigenic polypeptide and compositions containing the purified Ri antigenic polypeptide. Further provided by this invention is a antibody directed to an epitope on the Ri paraneoplastic antigenic polypeptide. Compositions containing this antibody also are provided by this invention. This invention also provides methods of diagnosis and treatment using the compositions described hereinabove.

REFERENCES:
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Furneaux, H.F. et al. Neurology 40:1085-1091. 1990.
Furneaux, H.F. et al. Proc. Natl. Acad. Sci USA 1990 86:2873-2877.
Dropcho, E.J. et al. Proc. Natl. Acad. Sci USA 84:4552-4556. 1987.
Korngreth, S.E. et al. Cancer Res. 46:2588-2595. 1986.
Ruddle-Steffen, C. et al. Ann. Neurol. 23:528-531. (abstract only) 1988.
Luque, F.A. et al. Ann. Neurol. 29:241-251. 1991.
Fathallah-Shaykh, H. et al. Proc. Natl. Acad. Sci USA 88:3451-3454. 1991.
Sakai, K. et al. Ann. Neurol. 28:692-698. 1990.
Furneaux, H.M. et al. New Engl. J. Med. 322:1844-1851.

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