Rhodotorula rubra useful in a process for the preparation of (.o

Details Rhodotorula rubra useful in a process for the preparation of (.o Rhodotorula rubra useful in a process for the preparation of (.o

1994-02-10

1995-12-05

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

435119, 435911, C12N 116

Patent

active

054728738

ABSTRACT:
A Rhodotorula rubra strain has been found which reduces pentoxifylline to 100% to give the S-alcohol. Moreover, other oxoalkylxanthine derivatives can also be converted into the corresponding S-alcohol. The microbiologically obtained S-(+)-enantiomers can then be converted stereo-selectively into the respective R-(-)-enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration cause an increase in cerebral blood flow.

REFERENCES:
patent: 4833146 (1989-05-01), Gerbert et al.
Jones et al., Tetrahedron 42:3351-3403 (1986).
Davis et al., Xenobiotica 15(12):1001-1010 (1985).
ATCC Catalogue of Fungi/Yeasts 267 (1984).
Saucier et al., J. Biol. Chem. 264(12):6863-6869 (1989).
Smith et al., J. Chrom. 281:281-287 (1983).
Davis et al., Appl. Env. Microbiol. 48(2):327-331 (1984).

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