Rhodanine derivatives and pharmaceutical compositions

Details Rhodanine derivatives and pharmaceutical compositions Rhodanine derivatives and pharmaceutical compositions

1988-11-09

1990-01-30

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548183, C07D27734, A01K 31425

Patent

active

048974064

ABSTRACT:
Disclosed are a compound of the formula ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl or a group --(CH.sub.2).sub.n COOR.sup.3 in which n is an integer of 1 to 4 and R.sup.3 is hydrogen or C.sub.1 -C.sub.6 alkyl, and R.sup.2 is a group --CH.dbd.CH--R.sup.4 or --CH.sub.2 --CH.sub.2 --R.sup.4 in which R.sup.4 is substituted or unsubstituted phenyl or a substituted or unsubstituted 5-membered heterocyclic group, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compounds have an excellent chemical mediator inhibitory activity.

REFERENCES:
patent: 3678041 (1972-07-01), Mousseron
patent: 4703052 (1987-10-01), Eggler
patent: 4714765 (1987-12-01), Ogawa et al.
patent: 4777259 (1988-10-01), Ogawa
patent: 4791126 (1988-12-01), Tanouchi

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