Rhodamine derivatives as fluorogenic substrates for proteinases

Details Rhodamine derivatives as fluorogenic substrates for proteinases Rhodamine derivatives as fluorogenic substrates for proteinases

1983-10-28

1985-12-10

Kight, John

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 549227, 436800, 435 4, 435 23, 435219, 435184, 435188, 25230116, C07G 700, C07D49310

Patent

active

045578621

ABSTRACT:
The present invention relates to a new class of novel Rhodamine derivatives. These derivatives which are bisamide substitution products are nonfluorescent. Whereas the monoamide substitution products exhibit high fluorescence. Cleavage of a single specified amide bond by bond-specific proteinases will therefore convert the nonfluorescent bisamide derivative into a highly fluorescent monoamide derivative.

REFERENCES:
patent: 4433156 (1984-02-01), Ishige et al.
patent: 4436926 (1984-03-01), Sato et al.
Chem. Abstract No. 208604b, Rhodamine-Based Compds. . . . Proteinases, Leytus et al., vol. 99, 1983.
Chem. Abstract No. 2653x, New Class of Sensitive and Selective . . . Derivatives of Rhodamine, Leytus vol. 100, 1984.

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