Rho target protein kinase p160

Details Rho target protein kinase p160 Rho target protein kinase p160

1996-07-24

2000-01-11

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

4352523, 43525233, 435325, 4353201, 536 231, 536 232, 536 235, 530300, 530350, C12N 912, C07K 1400

Patent

active

060134992

ABSTRACT:
The object of the present invention is to provide a target protein for the activated Rho protein. The present invention is a protein having the activated Rho protein binding activity and protein kinase activity, or derivatives thereof. The molecular weight of the protein is about 160 kDa as measured by SDS-PAGE. The protein kinase activity of the protein is enhanced when it binds to the activated Rho protein.

REFERENCES:
Manser et al. "A brain serine/threonine protein kinase activated by cdc42 and Rac1" Nature, 367, 40-46, Jan. 6, 1994.
Ishizaki et al. "The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr kinase homologous to myotonic dystrophy kinase" EMBO J., 15, 1885-1893, Apr. 15, 1996.
Matsui et al. "Rho-associated kinase, a novel serine/threonine kinase, as a putative target for the small GTP binding protein Rho" EMBO J. 15, 2208-2216, 1996.
Katz et al. "Differential expression of a novel protein kinase in human B lymphocytes" J. Biol. Chem. 269, 16802-16809, Jun. 1994.
Lim et al. "Regulation of phosphorylation pathways by p21 GTPase, the p21 Ras-related Rho subfamily and its role . . . " Eur. J. Biochem. 242, 171-185, 1996.
Leung et al. "The p160 RhoA-binding kinase ROKalpha is a member of the kinase family and is involve in the reorganization of cytoskeleton" Mol. Cellu. Biol. 16, 5313-5327, Oct. 1996.

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