Rho protein

Details Rho protein Rho protein

1999-10-12

2000-08-15

Prouty, Rebecca E

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435183, 435195, 536 231, 536 232, 536 235, C12N 1510, C12N 1509, C12N 1512

Patent

active

061034770

ABSTRACT:
The present invention provides a human Rho protein (HRHO) and polynucleotides which identify and encode HRHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing HRHO and for treating or preventing disorders associated with expression of HRHO.

REFERENCES:
Tavitian, A. "RAS proteins and related proteins." (title translated) C.R. Seances Soc.Biol.Fil. (1995) 189(1):7-12. (Abstract in English only).
Hall, A. et al., "Cellular responses regulated by rho-related small GTP-binding proteins." Philos.Trans.R.Soc.Lond. B. (1993) 340:267-271.
Chardin, P. et al., "Coding sequence of human rho cDNAs clone 6 and clone 9." Nuc.Acids Res. (1988) 16:2717. (GI 36034).
Segade, F. et al., "Isolation of Nine Gene Sequences Induced by Silica in Murine Macrophages" J.Immun. (1995)154:2384-2392.
Hotchin, N.A. et al., "The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases." J.Cell Biol. (1995) 131:1857-1865.
Segade, F. et al. (GI 1279555), GenBank Sequence Database (Accession X80638, X80898), National Center for Biotechnology Information, National Library of Medicine, Bethseda, Maryland, 20894. (GI 1279556).
Ren, M. et al. "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase." Proc.Acad.Sci. USA (1996) 93:5151-5155.
Database EMBL/GenBank, Accession No. L25081, Fagan et al., "Sequence of rhoC and rhoA small GTP-binding protein cDNAs from human retina", submitted 1993, available Jan. 9, 1995.
Georgiou, G., "Optimizing the Production of Recombinant Proteins in Microorganisms", AIChE Journal, 34: 1233-1248 (1988).
Shimizu, F., et al., "Isolation of a novel human cDNA (rhoHP1) homologous to rho genes", Bhiochemica et Biophysica Acta, 1351: 13-16 (1997).
EMBL Database entry HS122291, Accession No. N57122, Feb. 29, 1996, Hilllier, L. et al., The WashU-Merck EST project.
Symons, M., "Rho family GTPases: the cytoskeleton and beyond", Trends in Biochemical Sciences, 21: 178-181 (1996).
EMBL Database entry HSZZ14112, Accession No. AA308812, Apr. 18, 1997, Adams, M.D. et al., "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotifes of cDNA sequence".
Foster et al., "Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation, "Mol. Cell. Biol. 16(6) : 2689-2699.

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