.rho.-heteroatom-substituted phenols and uses thereof

Details .rho.-heteroatom-substituted phenols and uses thereof .rho.-heteroatom-substituted phenols and uses thereof

1995-01-20

1997-10-07

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514214, 514415, 514469, 514470, 540461, 540479, 540523, 546 94, 548491, 548510, 549466, 549471, A61K 3147, A61K 3134, A61K 3140, C07D20926, C07D45504

Patent

active

056748760

ABSTRACT:
The present invention provides an antiproliferative p-heteroatom-substituted phenol compound having the structure formula ##STR1## wherein m is 0 to 3, n is 0 to 4 when Het is nitrogen, wherein R is selected from the group consisting of hydrogen, alkyl, arylmethyl and acyl; R.sup.1 is alkyl; R.sup.2 is selected from the group consisting of hydrogen and alkyl; R.sup.3 is selected from the group consisting of alkyl and acyl when Het is nitrogen, R.sup.4 is selected from the group consisting of hydrogen and alkyl; R.sup.5 is selected from the group consisting of hydrogen and alkyl; and R.sup.6 and R.sup.7 are selected from the group consisting of hydrogen, alkyl and R.sup.6 and R.sup.7 together may represent oxygen. Also provided are various methods for the treatment of a pathological cell proliferative disease comprising administering to an animal) a pharmacologically and therapeutically effective dose of a pharmaceutical composition comprising a p-heteroatom-substituted phenols or an analog thereof.

REFERENCES:
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Kucklaender, U and Henze U. Arch. Pharm. 317(5) 394-403 (1984).
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