Rhizoxin derivatives and their use as anti-tumor agents

Details Rhizoxin derivatives and their use as anti-tumor agents Rhizoxin derivatives and their use as anti-tumor agents

1993-09-27

1994-10-04

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 81, 514 92, 540603, 544 587, 544127, 544235, 544238, 544333, 544364, 544405, 546122, 546141, 546148, 546153, 546157, 546168, 546196, 546270, 548113, 548181, 548235, 548236, A61K 3142

Patent

active

053526899

ABSTRACT:
Rhizoxin and rhizoxin-2-ene derivatives of formula ##STR1## in which: n is 1 to 25; A is an extra bond or oxygen, X is oxygen, sulfur, nitrogen or carbonyl; and R is hydrogen, carboxylic acyl having from 1 to 25 carbon atoms, alkoxycarbonyl group having from 2 to 26 carbon atoms, phosphono, alkylphosphono group in which the alkyl part has from 1 to 25 carbon atoms, dialkylphosphono group in which each alkyl part has from 1 to 25 carbon atoms, alkyl group having from 1 to 25 carbon atoms, aralkyl, cycloalkyl, heterocyclic, alkylthio group in which the alkyl part has from 1 to 25 carbon atoms, aralkylthio, or heterocyclylthio, or when X represents a nitrogen atom, R is R.sup.1 and R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, acyl, alkoxycarbonyl, phosphono, alkylphosphono or dialkylphosphono, have valuable anti-tumor activity. They may be prepared by acylation of rhizoxin or rhizoxin-2-ene.

REFERENCES:
patent: 4680178 (1987-07-01), Kiyoto et al.
patent: 4791128 (1988-12-01), Okuda et al.
Chem Abstr vol. 110 entry 212496f (1989) Abstracting JP Sankyo.
Ueda et al. Chem. Abstr vol. 113 No. 24 entry 218230y abstracting Japan 02196789 (1990).
Kaneko et al. Chem Abstr vol. 113 No. 13 entry 114948x abstracting Europe 350 315 (1990).
Chemical Abstracts, vol. 103, 1985, p. 374.
The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 10th Edition, 1983, p. 1408.
The Journal of Antibiotics, "Studies on Macrocyclic Lactone Antiobiotics VII.sup.1, Structure of a Phytotoxin Rhizoxin produced by Rhizopus Chinensis", Apr. 1984, pp. 354-362.

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