Rhesus HER2/neu, nucleotides encoding same, and uses thereof

Details Rhesus HER2/neu, nucleotides encoding same, and uses thereof Rhesus HER2/neu, nucleotides encoding same, and uses thereof

2007-10-16

2007-10-16

Spector, Lorraine (Department: 1646)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C530S350000, C536S023500, C435S069100, C435S320100, C435S252300, C435S254110

Reexamination Certificate

active

10541270

ABSTRACT:
Polynucleotides encoding rhesus monkey HER2
eu have been isolated, cloned and sequenced. The gene encoding the HER2
eu is commonly associated with the development of epithelial-derived human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the HER2
eu tumor-associated antigen, wherein aberrant HER2
eu expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector constructs carrying rhHER2
eu and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.

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