Rhenium and technetium complexes containing a hypoxia localizing

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

564253, 564268, 534 10, 534 14, C07D23354, C07C24900, C07F 500

Patent

active

058080910

ABSTRACT:
Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comnprising

REFERENCES:
patent: 4071613 (1978-01-01), Hunter, Jr.
patent: 4193979 (1980-03-01), Frank et al.
patent: 4272503 (1981-06-01), Camin et al.
patent: 4311689 (1982-01-01), Ruddock
patent: 4363793 (1982-12-01), Blau et al.
patent: 4431626 (1984-02-01), Henze
patent: 4444690 (1984-04-01), Fritzberg
patent: 4462992 (1984-07-01), Agrawal et al.
patent: 4615876 (1986-10-01), Troutner et al.
patent: 4638051 (1987-01-01), Burns et al.
patent: 4758682 (1988-07-01), Collins et al.
patent: 4789736 (1988-12-01), Canning et al.
patent: 4818813 (1989-04-01), Nowotnik et al.
patent: 4849511 (1989-07-01), Verbruggen
patent: 4871836 (1989-10-01), Francesconi et al.
patent: 4880616 (1989-11-01), Azuma et al.
patent: 4895960 (1990-01-01), Deutsch
patent: 4925650 (1990-05-01), Nosco et al.
patent: 4980147 (1990-12-01), Fritzberg et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 4988496 (1991-01-01), Srinivasan et al.
patent: 5026829 (1991-06-01), Deutsch
patent: 5037631 (1991-08-01), Nosco
patent: 5071636 (1991-12-01), Yamauchi et al.
patent: 5075099 (1991-12-01), Srinivasan et al.
patent: 5089249 (1992-02-01), Fritzberg et al.
patent: 5091514 (1992-02-01), Fritzberg et al.
patent: 5096693 (1992-03-01), Azuma et al.
patent: 5101041 (1992-03-01), Troutner et al.
patent: 5104638 (1992-04-01), Nosco
patent: 5116596 (1992-05-01), Bremer et al.
patent: 5116598 (1992-05-01), Noco
patent: 5164175 (1992-11-01), Bremer et al.
patent: 5164176 (1992-11-01), Gustavson et al.
patent: 5187264 (1993-02-01), Verbruggen
patent: 5302370 (1994-04-01), Neumeier et al.
Chapman, J.D., "Measurement of Tumor Hypoxia by Invasive and Non-Invasive Procedures: A Review of Recent Clinical Studies", Radiother. Oncol., 20, pp. 13-19 (1991). H!Fluoromisonidaozle in Ischemic Myocardium", J. Nucl. Med., vol. 30, No. 2, 194-201 (1989). in Cerebral Ischemia", Stroke, 18:168-176 (1987). Fluoromisonidazole", J. Nucl. Med., 30,789 (No. 252) (1989).
Biskupiak, J.E. et al., "Synthesis of an (Iodovinyl)misonidazole Derivative for Hypoxia Imaging", J. Med. Chem., 34, pp. 2165-2168 (1991).
Chapman, J.D., "The Detection and Measurement of Hypoxic Cells in Solid Tumors", Cancer, vol. 54, No. 11, pp. 2441-2449 (1984).
Kedderis, G.L. et al., "The Metabolic Activation of Nitroheterocyclic Therapeutic Agents", Drug Metabolism Reviews, 19(1), pp. 33-62 (1988).
Adams, G.E. et al., "Hypoxia-Mediated Nitro-Heterocyclic Drugs in The Radio-and Chemotherapy of Cancer", Biochemical Pharmacology, vol. 35, No. 1, pp. 71-76 (1986).
Brown, D.M. et al., "Structure-Activity Relationships of 1-Substituted 2-Nitroimidazoles: Effect of Partition Coefficient and Side-chain Hydroxyl Groups on Radiosensitization In Vitro", Radiation Research, 90, pp. 98-108 (1982).
Adams, G.E., et al., "Structure Activity Relationships in the Development of Hypoxic Cell Radiosensitizers. I. Sensitization Efficiency", Int. J. Radiat. Biol., vol. 35, No. 2, pp. 133-150 (1979).
Adams, G.E., et al., "Structure Activity Relationships in the Development of Hypoxic Cell Radiosensitizers. III. Effects of Basic Substituents in Nitroimidazole Sidechains", Int. J. Radiat. Biol., vol. 38, No. 6, pp. 613-626 (1980).
Jerabek, P.A., et al., "Synthesis and Biodistribution of .sup.18 F-Labeled Fluoronitroimidazoles: Potential In Vivo Markers of Hypoxic Tissue", Appl. Radiat. Isot. vol. 37, No. 7, pp. 599-605 (1986).
Martin, G. V. et al., "Fluoromisonidazole A Metabolic Marker of Myocyte Hypoxia" Circulation Research, 67, pp. 240-244 (1990).
Shelton, M.E. et al., "In Vivo Delineation of Myocardial Hypoxia During Coronary Occlusion Using Fluorine-18 Fluoromisonidazole and Positron Emission Tomography: A Potential Approach for Identification of Jeopardized Myocardium", J. Am. College Cardiology, vol. 16, No. 2, pp. 477-485 (Aug. 1990).
Mannan, R. H. et al., "Radioiodinated 1-(5-Iodo-5-deoxy-.beta.-D-arabinofuranosyl)-2-nitroimidazole (Iodazomycin Arabinoside: IAZA): A Novel Marker of Tissue Hypoxia", The Journal of Nuclear Medicine, vol. 32, No. 9, pp. 1764-1770 (1991).
Parker, D., "Harnessing the Kinetic Stability of Macrocyclic Complexes In Vivo," presented at the 16th Int. Symp. on Macrocyclic Chemistry, Univ. of Sheffield, UK (Sep. 1-6, 1991).
Yang, L. et al., "Synthesis of Metronidazole Derivative and Its Distribution in Sarcoma 180 Bearing Mice", J. of Medical Colleges of PLA; 2(3) pp. 265-269 (1987).
Volkert, W.A. et al., ".sup.99m Tc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceutical", Eur. J. Nucl. Med., 9, pp. 511-516 (1984).
Kung, H.F., et al., "Synthesis and Biodistribution of Neutral Lipid-Soluble Tc-99m Complexes that Cross the Blood-Brain Barrier", The Journal of Nuclear Medicine, 25, pp. 326-332 (1984).
Lever, S.Z. et al., "Design, Preparation, and Biodistribution of a Technetium-99m Triaminedithiol Complex to Assess Regional Cerebral Blood Flow", J. Nucl. Med., 26, pp. 1287-1294 (1985).
Jurisson et al., "Synthesis, Characterization, and X-ray Structural Determination of Technetium (V)-Oxo-Tetradentate Amine Oxime Complexes", Inorg. Chem., 25, pp. 543-549 (1986).
Ding et al., "Review and Prospectives of Brain Radiopharmaceuticals", Nucl. Sci. J., 29(5), pp. 341-348 (1992).
Fattorusso et al., J. Chem. Soc., Daltons Trans., p. 752 (1970).
Moody et al., J. Chem. Soc. Perkin Trans, 1, (1), pp. 18-24 (1972).
Hook et al., Anti-Cancer Drug Res., 4(3), pp. 173-190 (1989).
Orna et al., Correlation of Kinetic Parameters of Nitroreductase Enzymes with Redox Properties of Nitroaromatic Compounds, J. Biol. Chem., vol. 264, 21, pp. 12379-12384 (1989).
Murmann, K., "The Interaction of 2-Methyl-2-amino-3-butanone Oxime with Nickel(II) and Copper (II) Ions", J. Am. Chem. Soc., pp. 4174-4180 (1958).
Vassian et al., "Aromatization of an Aliphatic Amine Oxime Nickel(II) Complex by Molecular Oxygen", Inorg. Chemisty, vol. 6, No. 11, pp. 2043-2046 (1967).
Murmann et al., "An Unsymmetrical transDinitrocobalt(III) Complex. A Crystal Structure Determination," Inorg. Chem., vol. 12, No. 11, pp. 2625-2631 (1973).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Rhenium and technetium complexes containing a hypoxia localizing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Rhenium and technetium complexes containing a hypoxia localizing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rhenium and technetium complexes containing a hypoxia localizing will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-89489

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.