RGD (Arg-Gly-Asp) coupled to (neuro)peptides

Details RGD (Arg-Gly-Asp) coupled to (neuro)peptides RGD (Arg-Gly-Asp) coupled to (neuro)peptides

2007-04-10

2007-04-10

Kemmerer, Elizabeth (Department: 1649)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Somatostatin ; related peptides

C530S317000, C424S001450, C514S009100

Reexamination Certificate

active

10258766

ABSTRACT:
The invention relates to compounds having a binding affinity for both the αvβ3 receptor and a (neuro)peptide receptor, in particular the somatostatin receptor, which compound comprises a first peptide part comprising at least once the amino acid sequence Arg-Gly-Asp, and a second peptide part coupled thereto, optionally via a linker, which second peptide part is a (neuro)peptide.

REFERENCES:
patent: 0385659 (1990-02-01), None
patent: PCT/EP01/04764 (2002-02-01), None
Trulsson et al., Cholecystokinin octapeptide induces both proliferation and apoptosis in the rat pancreas, Regul. Pept., 98(1-2):41-48, Apr. 2, 2001.
Karki et al., Arch. Of Biochem. & Biophys., Kinetic comparison of procaspase-3 and caspase 3, 442:125-32, 2005.
Huang et al., Chemistry & Biology, Jul. 7, 2000(7):453-61.
Buckley, Christopher D., Pilling, Darrell, Henriquez, Nick V., Parsonage, Greg, Threlfall, Katy, Scheel-Teollner, Dagmar, Simmons, David L., Akbar, Arne N., Lord, Janet M., Salmon, Mike;RGD Peptides Induce Apoptosis by Direct Caspase-3 Activiation; Nature; Feb. 11, 1999; pp. 534-539; vol. 397; Macmillan Magazines, Ltd.
DeJong, Marion, Breeman, W.A.P., Bernard, H.F., Kooij, P.P.M., Slooter, G.D., Van Eijck, C.H.J., Kwekkeboom, D.J., Valkema, R., Macke, H.R., Krenning, E.P.;Therapy of Neuroendocrine Tumors with Radiolabeled Somatostatin-Analogues; Quarterly Journal of Nuclear Medicine; 1999; pp. 356-365; vol. 43, No. 4.
Vella, F., Hernandez, J.F., Molla, A., Block, M.R., Arlaud, G.J.;Grafting An RGD Motif Onto An Epidermal Growth Factor-like Module: Chemical Synthesis and Functional Characterization of the Chimeric Molecule; Journal of Peptide Research; 1999; pp. 415-426; vol. 54.
Humphries et al., A Synthetic Peptide from Fibronectic Inhibits Experimental Mestasis of Murine Melanoma Cells, Science, 1986, pp. 467-470.
Ferguson, et al., Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo, Proc Natl Acad Sci, 1991, pp. 8072-8076, vol. 88.
Brooks et al., Integrin Antagonists Promote Tumor Regression by Inducing Apoptosis of Angiogenic Blood Vessels, Cell, 1994, pp. 1157-1164, vol. 79.
Boucaut et al., Biologically Active Synthetic Peptides as Probes of Embryonic Development: A Competitive Peptide Inhibitor of Fibronectin Function Inhibits Gastrulation in Amphibian Embryos and Neural Crest Cell Migration in Avian Embryos, J Cell Biol, 1984, pp. 1822-1830, vol. 99.
Capello et al., Increased Cell Death After Therapy with an Arg-Gly-Asp-Linked Somatostatin Analog, J Nucl Med, 2004, pp. 1716-1720, vol. 45.
van Hagen et al., “Evaluation of a radiolabelled cyclic DTPA-RGD analogue for tumour imaging and radionuclide therapy.” Int J Cancer. Aug. 20, 2000;90(4):186-98.
Bernard et al., “Radiolabeled RGD-DTPA-Tyr3-octreotate for receptor-targeted radionuclide therapy.” Cancer Biother Radiopharm. Apr. 2004;19(2):173-80.
Capello et al., “Anticancer activity of targeted proapoptotic peptides.” J Nucl Med. Jan. 2006;47(1):122-9.

Affiliated with

Also associated with

Rating

RGD (Arg-Gly-Asp) coupled to (neuro)peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with RGD (Arg-Gly-Asp) coupled to (neuro)peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and RGD (Arg-Gly-Asp) coupled to (neuro)peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3724491