RFRP-3 and DNA thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

Reexamination Certificate

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Details

C530S328000, C530S329000

Reexamination Certificate

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07041789

ABSTRACT:
The RFRP-3 peptide of the present invention which is an agent for promoting prolactin secretion is useful as a prophylactic and/or therapeutic agent for various diseases associated with prolactin secretion, such as hypoovarianism, seminal vesicle hypoplasia, menopausal syndrome and hypothyroidism.

REFERENCES:
patent: WO 00/29441 (2000-05-01), None
patent: WO 01/66134 (2001-09-01), None
patent: WO 02/46405 (2002-06-01), None
Shintani et al. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.Pharmaceutical Discovery Research Division, . Nat Cell Biol. 2000 Oct;2(10):703-8.
Hinuma, et al. “New neuropeptides containing carboxy-terminal Rfamide and their receptor in mammals” Nature Cell Biology2: 703-708 (2000).
Liu, et al. “Identification and Characterization of Novel Mammalian Neuropeptide FF-like Peptides That Attenuate Morphine-induced Antinociiception” The Journal of Biological Chemistry 276(40): 36961-36969 (2001).

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