Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Thermal applicators
Reexamination Certificate
1998-08-28
2001-11-20
Dvorak, Linda C. M. (Department: 3739)
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Thermal applicators
C607S098000, C606S045000, C606S041000
Reexamination Certificate
active
06321120
ABSTRACT:
FIELD OF INVENTION
This invention generally relates to apparatus and methods for treating cancer and other illness in humans and animals, and more particularly to a therapeutic apparatus and method based upon the administration of precisely regulated, low power, pulsed electromagnetic radiation (EMR).
BACKGROUND OF THE INVENTION
There is a considerable body of early literature regarding treatment of various illnesses with radio frequencies (RE) in the 43 MHz range. In U.S. Pat. No. 2,545,087, 1. J. Hart disclosed an apparatus for treating a subject with a sequence of radio frequencies in the 43 MHz. range, applied in a stepwise fashion. These frequencies were each modulated sinusoidally at 60 Hz., and further pulsed by a second slow sinusoidal oscillator operating at 90 cycles per minute (1.5 Hz.). The RF frequencies employed by Hart were specified to three decimal places.
The instruments available to Hart and the other researchers of his day were based on tube amplifiers, which resulted in oscillators with considerable drift that could not be precisely tuned. Hart's means for applying the RF energy to a subject most often consisted of a metal plate acting as an antenna. As a result of such oscillator drift and imprecision, and the inefficiency of the available output devices, Hart and his contemporaries were not able to conduct scientific tests with precisely controlled frequencies, or to discover optimal treatment modalities.
Modern electronic technologies make it relatively simple to construct more precise and stable instruments than Hart had at his disposal. As a consequence, it has become possible to study systematically the potential therapeutic value of EMR. The present inventors have undertaken such studies over the course of many years, and as a result have perfected apparatus and methods which have proved effective in treating cancerous tumors in laboratory mice. The inventors believe that the same methods can be effectively adapted for human treatment.
The present inventors have constructed apparatus designed to overcome the limitations of Hart's approach. They have further sought to establish the utility of their invention through a program of animal testing, and have in turn used the results of such testing to refine the apparatus and the methods for effectively using such apparatus. The resulting apparatus and methods, and the experimental results of applying such apparatus and methods to treat cancerous tumors in mice, will be described below.
SUMMARY OF THE INVENTION
It is generally the object of the present invention to utilize electromagnetic radiation to provide effective treatments for cancer and other illnesses.
It is a further object of this invention to achieve reliable and reproducible therapeutic results from EMR treatment methods by achieving precise control over the treatment frequency.
It is also an object of the present invention to provide an efficient means of transmitting EMR from the generating means to the subject.
It is another object of the present invention to provide an EMR treatment that may be applied at very low power levels that can cause no harm.
These and other objects are achieved in accordance with the present invention through the use of an apparatus involving an oscillator that outputs, at a power of less than one mw, an RF frequency in the 43 MHz range, regulated and stabilized to the fifth or sixth decimal place, which is in turn modulated with a 60 Hz. 50% duty cycle square wave, which is in turn gated, again on a 50% duty cycle, at a rate of 1.167 Hz. (70 pulses per minute).
The RF frequency is chosen for a particular subject based on the believed effectiveness of the frequency in treating the illness in question, as summarized herein.
The modulated RF signal output by the apparatus of the present invention is applied to a flat loop of wire approximately 60 cm. long, grounded at one end and wound in five flat, concentric spiralrectangular turns spaced about 3.175 mm. apart, the loop (herein referred to as a “treatment loop”) being mounted on an insulating layer adhesively bonded to a metal plate.
In using this apparatus, the metal plate is placed loop down, on the subject's body near the area to be treated. RF power is applied to the loop at one precise treatment RF frequency for at least one hour at a time. During treatment, the treatment loop is shielded from direct light and moving air currents.
There are alternative embodiments of the invention that differ somewhat in their circuit and construction details. The first, referred to as the “Battery SCPO,” is a battery-powered “Single Crystal Pulsed Oscillator” in a metal housing with an internal quartz crystal, and an integral, externally mounted treatment loop. Each Battery SCPO is limited to a single frequency. A variation is shown (the “Mouse SCPO”) in which an SCPO is powered by an external DC power module rather than batteries. An alternate embodiment, referred to as the “Generator Embodiment”, derives its treatment signal from the modulated output of a Hewlett-Packard Model 8662A frequency generator, and supplies the signal to the treatment loop over a short coaxial cable. The frequency and power of the Generator Embodiment is easily adjusted with controls on the front panel of the 8662A frequency generator. Another alternative embodiment, also based on the HP 8662A Frequency Generator, modulates the RF signal entirely externally to the HP 8662A, and employs a specific type of coaxial cable to carry the signal from the modulator to the treatment loop. These alternative embodiments differ somewhat in their circuitry and construction details, as will be more fully described below.
In any of the alternative embodiments, treatment is non-restrictive and utilizes a low power believed to be completely safe for humans.
Other features and advantages of the present invention will become apparent from the following more detailed description, taken in conjunction with the accompanying drawings, which illustrate, by way of example, the principles of the invention.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGS. 1A and 1B
show top and bottom external views of the Battery SCPO.
FIG. 2
is a block diagram of the major functional units of the Battery SCPO.
FIG. 3
is a schematic diagram of the Battery SCPO.
FIG. 4A
shows the modulation waveform of the Battery SCPO.
FIGS. 4B through 4F
show spectrum analyses of the output of the Battery SCPO.
FIG. 5
is an external vies of the components of the Generator Embodiment.
FIG. 6
is a schematics diagram of the modulator circuit for the Generator Embodiment.
FIGS. 7A and 7B
show respectively, the modulation waveform and a portion of the output waveform of the Generator Embodiment.
FIGS. 8A and 8B
show front and back views of the treatment loop used in connection with the Generator Enmbodiment.
FIGS.
9
A
1
-
9
J
4
show the treatment housings and treatment loops used for treating mice in the experiments described herein.
FIGS. 10 through 29
show, for each treated and control mouse involved in the inventors' experimental studies, A, the locations of the tumors (if any) that developed, B, plots (on a logarithmic scale) of the respective volumes of the various tumors as a function of time, and C, plots of the mouse's weight and hematocrit measurements as a function of time.
FIGS. 30A and B
shows bar graphs of the life spans of the treated and control mice, respectively.
FIGS. 31A and B
shows bar graphs of the life spans of the treated and control mice, respectively, after tumors were detected.
FIGS. 32A and B
shows bar graphs of the number of tumors in the treated and control mice, respectively.
FIGS. 33A and B
shows bar graphs of the outcome with respect to the tumors found in the treated and control mice, respectively.
FIGS. 34A and B
shows bar graphs of the weight changes observed in the treated and control mice, respectively.
FIGS. 35A and B
shows bar graphs of the maximum size of tumors observed in the treated and control mice, respectively.
FIG. 36
is a schematic diagram for an external modulator that attach
Devries Robert L.
Surbeck Homer L.
Surbeck Margaret P.
Abramson Ronald
Dvorak Linda C. M.
Hughes Hubbard & Reed LLP
INDNJC, Inc.
Kearney R.
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