Revertant serotype 1 Marek's disease vaccine

Details Revertant serotype 1 Marek's disease vaccine Revertant serotype 1 Marek's disease vaccine

1987-07-10

1990-01-23

Huleatt, Jayme A.

Drug, bio-affecting and body treating compositions

Lymphokine

424 93, 4351721, 435237, 435948, 935 63, 935 65, 935 70, A61K 3912, A61K 3700, C12N 1500, C12N 708, C12R 191

Patent

active

048957178

ABSTRACT:
A Marek's disease vaccine comprising either a revertant virus derived by backpassaging an attenuated serotype 1 Md11 virus or an antigenic component of the virus is characterized by increased levels of replicative ability and protectivity in chickens as compared to the original attenuated strain. Revertants of the invention are exemplified by a clone identified as Md11/75C/R2 and can be formulated into monovalent and polyvalent vaccines.

REFERENCES:
R. L. Witter, "Protection by Attenuated and Polyvalent Vaccines Against Highly Virulent Strains of Merek's Disease Virus," Avian Pathol. 11: 49-62 (1982) [#S452].
R. L. Witter et al., "Polyvalent Marek's Disease Vaccines: Safety, Efficacy and Protective Synergism in Chickens with Maternal Antibodies," Avian Pathol. 13: 75-92 (1984) [#S501].
Paoletti et al., (1984) PNAS 81:193.

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