Reversibly blocked plasmin, t-PA hybrid fibrinolytic enzymes and

Details Reversibly blocked plasmin, t-PA hybrid fibrinolytic enzymes and Reversibly blocked plasmin, t-PA hybrid fibrinolytic enzymes and

1988-02-22

1990-03-13

Huleatt, Jayme A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Multienzyme complexes or mixtures of enzymes

424 9464, 435212, 435217, 435226, A61K 3762, A61K 37547, C12N 948, C12N 968

Patent

active

049082043

ABSTRACT:
A fibrinolytically active hybrid protein which comprises one chain of a 2-chain protease linked to a chain of a different 2-chain protease, or to the same chain of the same protease, at least one of the chains in the hybrid protein being derived from a fibrinolytically active protease, such that the hybrid protein has a catalytic site essential for fibrinolytic activity which is optionally blocked by a removable blocking group.

REFERENCES:
patent: 4082612 (1978-04-01), Robbins et al.
patent: 4285932 (1981-08-01), Smith
patent: 4507283 (1985-03-01), Smith
patent: 4545988 (1985-10-01), Nakayama et al.
patent: 4600580 (1986-07-01), Smith
Summaria et al., J. Biol Chem, vol. 254, pp. 6811-6814, 1979.
Robbins et al, Biochemistry, vol. 25, pp. 3603-3611, Jun. 1986.
Jackson et al, Biochem. 1982, 21, 6620-6625.
Summaria et al, J. Biol Chem. 251, No. 18, 5810-5813 (1976).

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