Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Reexamination Certificate
2007-08-03
2010-12-07
Fetterolf, Brandon J (Department: 1628)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
C514S274000, C514S588000, C514S647000, C514S256000
Reexamination Certificate
active
07846469
ABSTRACT:
Methods and pharmaceutical compositions are disclosed for reversibly inhibiting sperm receptor activity in animals. Nicarbazin, its derivatives and modifications which retain pharmacological activity are shown to inhibit activity of zona pellucida proteins and concomitant synthesis and/or assembly of the sperm receptor on the oocyte surface necessary for fertilization. Nicarbazin is easily administered, for example by simple addition to feed of an animal and is and non-toxic to the animals, providing a safe and efficient means for controlling populations of mammals and avian species.
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Barbato Guy F.
MacDonald Alexander
Fetterolf Brandon J
McKee Voorhees & Sease, P.L.C.
Pagonakis Anna
The Penn State Research Foundation
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