Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1997-10-22
2000-07-18
Achutamurthy, Ponnathapu
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
530350, 424445, 424 7802, 424 7806, 514 2, C07K 1400, A61K 3174, A61K 3800
Patent
active
060909110
ABSTRACT:
The invention is based on the discovery that a block copolymer that includes .alpha.-helical blocks, e.g., terminal blocks, which form intermolecular coiled-coil structures, and one or more random-coil blocks, which link the .alpha.-helical blocks, can form suspensions that can reversibly gel to form monodisperse hydrogels. The transition between the gel and liquid phases depends on pH, temperature, concentration, and chemical structure. The copolymers can be synthesized biologically through genetic engineering.
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Petka et al., "Surface Recognition and Diffusion of Engineered Macromolecules," Polymer Preprints, vol. 35(2), pp. 452-453, 1994.
McGrath Kevin P.
Petka Wendy A.
Tirrell David A.
Achutamurthy Ponnathapu
Tung Peter P.
University of Massachusetts
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