Reversible geling co-polymer and method of making

Details Reversible geling co-polymer and method of making Reversible geling co-polymer and method of making

2005-12-27

2005-12-27

Mullis, Jeffrey (Department: 1711)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C525S054200, C525S054300, C525S054100, C424S488000

Reexamination Certificate

active

06979464

ABSTRACT:
The present invention is a thereapeutic agent carrier having a thermally reversible gel or geling copolymer that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum geling molecular weight cutoff and a therapeutic agent.

REFERENCES:
patent: 4147764 (1979-04-01), Levy et al.
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4732930 (1988-03-01), Tanaka et al.
patent: 5000955 (1991-03-01), Gould et al.
patent: 5053228 (1991-10-01), Mori et al.
patent: 5124151 (1992-06-01), Viegas et al.
patent: 5226902 (1993-07-01), Bae et al.
patent: 5252318 (1993-10-01), Joshi et al.
patent: 5262055 (1993-11-01), Bae et al.
patent: 5278201 (1994-01-01), Dunn et al.
patent: 5290494 (1994-03-01), Coombes et al.
patent: 5292517 (1994-03-01), Chang
patent: 5410016 (1995-04-01), Hubbell et al.
patent: 5441732 (1995-08-01), Hoeg et al.
patent: 5449513 (1995-09-01), Yokoyama et al.
patent: 5462990 (1995-10-01), Hubbell et al.
patent: 5484610 (1996-01-01), Bae
patent: 5514379 (1996-05-01), Weissleder et al.
patent: 5525334 (1996-06-01), Ito et al.
patent: 5575815 (1996-11-01), Slepian et al.
patent: 5580929 (1996-12-01), Tanaka et al.
patent: 5624685 (1997-04-01), Takahashi et al.
patent: 5631337 (1997-05-01), Sassi et al.
patent: 5634946 (1997-06-01), Slepian
patent: 5643246 (1997-07-01), Leeb et al.
patent: 5702717 (1997-12-01), Cha et al.
patent: 5752974 (1998-05-01), Rhee et al.
patent: 5788687 (1998-08-01), Batich et al.
patent: 5820879 (1998-10-01), Fernandez et al.
patent: 5843156 (1998-12-01), Slepian et al.
patent: 5843331 (1998-12-01), Schober et al.
patent: 5858746 (1999-01-01), Hubbell et al.
patent: 5876741 (1999-03-01), Ron
patent: 5939485 (1999-08-01), Bromberg et al.
patent: 5942209 (1999-08-01), Leavitt et al.
patent: 5954706 (1999-09-01), Sahatjian
patent: 5969052 (1999-10-01), Mumick et al.
patent: 5976648 (1999-11-01), Li et al.
patent: 5998588 (1999-12-01), Hoffman et al.
patent: 6015541 (2000-01-01), Greff et al.
patent: 6030634 (2000-02-01), Wu et al.
patent: 6060582 (2000-05-01), Hubbell et al.
patent: 6065572 (2000-05-01), Schober et al.
patent: 6083524 (2000-07-01), Sawhney et al.
patent: 6290729 (2001-09-01), Slepian et al.
patent: 6296831 (2001-10-01), Weller et al.
patent: 6352682 (2002-03-01), Leavitt et al.
patent: 6417247 (2002-07-01), Armstrong et al.
patent: 6486213 (2002-11-01), Chen et al.
patent: 6734147 (2004-05-01), Levy
patent: 6869588 (2005-03-01), Weller et al.
patent: 2001/0046518 (2001-11-01), Sawhney
patent: 0 534 015 (1991-09-01), None
patent: 534015 (1993-03-01), None
patent: 0 704 217 (1996-04-01), None
patent: 06-293632 (1994-10-01), None
patent: PCT/US91/04104 (1990-06-01), None
patent: PCT/US91/01884 (1991-03-01), None
patent: WO 91/15526 (1991-10-01), None
patent: WO 91/19481 (1991-12-01), None
patent: WO 95/00162 (1995-01-01), None
patent: WO 95/07719 (1995-03-01), None
patent: WO 95/24430 (1995-09-01), None
patent: WO 96/03112 (1996-02-01), None
patent: PCT/US96/10376 (1996-06-01), None
patent: WO 97/00275 (1997-01-01), None
patent: WO 97/09068 (1997-03-01), None
patent: WO 99/07343 (1999-02-01), None
patent: WO 99/49908 (1999-10-01), None
patent: WO 99/55386 (1999-11-01), None
patent: WO 00/07603 (2000-02-01), None
PH Sensitive Hydrogels Based on Thermally Reversible Gels for Enteric Drug Delivery, LC Dong, AS Hoffman, P Sadumi, Proceed. Intern. Symp. Control. Rel. Vioac. M., 18, (1989), Controlled Release Society, P 95-96.
Lower Critical Solution Temperatures of Aqueous Copolymers of N-Isopropylacrylamide and Other N-Substituted Acrylamides, JH Priest, SI Murray, RJ Nelson, AS Hoffman, Reversible Polymeric Gels and Related Systems, Chapter 18, American Chemical Society, 1987.
Development if Injectable Sustained-Release Gels for Site-Specific Treatment of Solid Tumors andCondylomata acuminata,R. Jones, 6th Int. Symp. on Recent Advances in Drug Delivery Systems, Feb. 22-25, 1193, SLC, UT.
Graft Copolymers that Exhibit Temperature-Induced Phase Transitions Over a Wide Range of PH, G Chen, AS Hoffman, Letters to Nature, Nature vol. 373, Jan. 5, 1995, P 49-52.
Inverse Thermally-Reversible Gelation of Aqueous N-Isopropylacrylamide Copolymer Solutions, CK Han, YH Bae, Polymer, vol. 39, No. 13, pp. 2809-2814, 1998.
Thermally Reversible Polymer Gels for Biohybrid Artificial Pancreas, B Vernon, Macromol. Symp., vol. 9, pp. 155-167, 1996.
Bae et al., “Temperature Dependence of Swelling of Crosslinked Poly(N,N′-alkyl substituted acrylamides) in Water,” Journal of Polymer Science: Part B: Polymer Physics, vol. 28, p. 923-936, 1990.
Beltran et al., “Swelling Equilibria for Weakly Ionizable, Temperature-Sensitive Hydrogels,” Macromolecules, vol. 24, p. 549-551, 1991.
Brazel et al., “Temperature- and pH- Sensitive Hydrogels for Controlled Release of Antithrombotic Agents,” Materials Research Society Symposium Proceedings, vol. 331, p. 211-216, 1994.
Chen et al., “A New Temperature- and pH-Responsive Copolymer for Possible Use in Protein Conjugation,” Macromolecular Chemistry and Physics, vol. 196, p. 1251-1259, 1995.
Feil et al., “Effect of Comonomer Hydrophilicity and Ionization on the Lower Critical Solution Temperature of N-Isopropylacrylamide Copolymers,” Macromolecules, vol. 26, p. 2496-2500, 1993.
Gutowska et al., “Thermosensitive Polymers for Drug Delivery,” Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), vol. 37, No. 2, p. 115-116, 1996.
Hoffman et al., “Conjugates of Stimuli-Responsive Polymers and Biomolecules,” Macromolecular Symposia, vol. 118, p. 553-563, 1997.
Hoffman, “Intelligent Polymers in Medicine and Biotechnology,” Artificial Organs, vol. 19, No. 5, p. 458-467, May 1995.
Hoffman, “Environmentally Sensitive Polymers and Hydrogels,” MSR Bulletin, vol. 16, No. 9, p. 42-46, Sep. 1991.
Jeong et al., “Biodegradable Block Copolymers as Injectable Drug-Delivery Systems,” Nature, vol. 388, No. 6645, p. 860-862, Aug. 1997.
Okano et al., “Temperature-Responsive Poly(N-Isopropylacrylamide) as a Modulator for Alteration of Hydrophilic/Hydrophobic Surface Properties to Control Activation/Inactivation of Platelets,” Journal of Controlled Release, vol. 36, p. 125-133, 1995.
Park et al., “Effect of Temperature Cycling on the Activity and Productivity of Immobilized β-Galactosidase in a Thermally Reversible Hydrogel Bead Reactor,” Applied Biochemistry and Biotechnology, vol. 19, p. 1-9, 1988.
Park et al., “Immobilization and Characterization of β-Galactosidase in Thermally Reversible Hydrogel Beads,” Journal of Biomedical Materials Research, vol. 24, p. 21-38, 1990.
Takei et al., “Temperature-Modulated Platelet and Lymphocyte Interactions with Poly(N-Isopropylacrylamide)-Grafted Surfaces,” Biomaterials, vol. 16, No. 9, pp. 667-673, 1995.
Vernon et al., “In Vitro Insulin Release of Rat Islets Entrapped in Thermally Reversible Polymer Gel,” Proceedings of the International Symposium on Controlled Release of Bioactive Materials, 23rd, p. 216-217, 1996.
Yan et al., “Polymer Communications,” Polymer, vol. 36, No. 4, p. 887-889, 1995.
Park et al., “Synthesis, Characterization, and Application of pH/Temperature-Sensitive Hydrogels,”Proceed. Intern. Symp. Control. Rel. Bioact. Mater., vol. 17, pp. 112-113, 1990.
Vakkalanka et al., “Temperature-and pH-Sensitive Terpolymers for Modulated Delivery of Streptokinase,”J. Biomater. Sci. Polymer Edn., vol. 8, No. 2, pp. 119-129, 1996.

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