Reversible gelation emulsion compositions and methods of use

Details Reversible gelation emulsion compositions and methods of use Reversible gelation emulsion compositions and methods of use

1992-03-18

1995-08-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

514912, 514913, 514914, 514915, 514938, 514942, A61K 3119, A61K 31745, A61K 4738, A01N 2504

Patent

active

054417325

ABSTRACT:
Reversibly gelling aqueous and oil emulsions are disclosed which can be modified to incorporate oil soluble pharmaceutical compounds for delivery to physiological systems in a soluble form and which undergo significant changes in viscosity in response to substantially simultaneous changes in both temperature and pH. The compositions are formed of relatively low concentrations of a stable combination of at least one pH-sensitive reversibly gelling polymer, at least one temperature-sensitive reversibly gelling polymer and at least one organic oil. The compositions can be formulated to exhibit a sol-gel transition over a wide range of conditions and viscosities and may be modified to incorporate a pharmaceutical compound for utilization as droppable or injectable drug delivery systems which will gel following administration to a physiological system for the sustained delivery of such pharmaceutical compounds.

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European Patent Office, Supplementary European Search Report EP 91 91 2727, The Hague, 23 Feb. 1993, 6 pages.

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