Reversible gelation compositions and methods of use

Details Reversible gelation compositions and methods of use Reversible gelation compositions and methods of use

1990-06-15

1993-10-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

424422, 424427, 424428, 424 2, 514912, 514913, 514914, 514915, A61K 3119, A61K 31745, A61K 4738, A01N 2504

Patent

active

052523187

ABSTRACT:
Reversibly gelling aqueous compositions are disclosed which undergo significant changes in viscosity in response to substantially simultaneous changes in both temperature and pH. The compositions are formed of relatively low concentrations of a stable combination of at least one pH-sensitive reversibly gelling polymer and at least one temperature-sensitive reversibly gelling polymer. The compositions can be formulated to exhibit a sol-gel transition over a wide range of conditions and viscosities and may be modified to incorporate a pharmaceutical compound for utilization as droppable or injectable drug delivery systems which will gel following administration to a physiological system for the sustained delivery of such pharmaceutical compounds.

REFERENCES:
patent: 4271143 (1981-06-01), Schoenwald et al.
patent: 4407792 (1984-10-01), Schoenwald et al.
patent: 4474751 (1984-10-01), Haslam et al.
patent: 4474752 (1984-10-01), Haslam et al.
patent: 4474753 (1984-10-01), Haslam et al.
patent: 4615697 (1986-10-01), Robinson
patent: 4692454 (1987-09-01), Mich et al.
patent: 4911920 (1990-03-01), Jani et al.

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