Reversible electrochemical sensors for polyions

Details Reversible electrochemical sensors for polyions Reversible electrochemical sensors for polyions

2004-07-08

2009-06-30

Olsen, Kaj K (Department: 1795)

Electrolysis: processes, compositions used therein, and methods

Electrolytic analysis or testing

For ion concentration

C205S789000, C205S792000, C204S296000, C204S418000

Reexamination Certificate

active

07553403

ABSTRACT:
The present invention is directed to a reversible electrochemical sensor for polyions. The sensor uses active extraction and ion stripping, which are controlled electrochemically. Spontaneous polyion extraction is suppressed by using membranes containing highly lipophilic electrolytes that possess no ion-exchange properties. Reversible extraction of polyions is induced by constant current pulse of fixed duration applied across the membrane. Subsequently, polyions are removed by applying a constant stripping potential. The sensors provide excellent stability and reversibility and allow for measurements of heparin concentration in whole blood samples via protamine titration.

REFERENCES:
patent: 4707378 (1987-11-01), McBride et al.
patent: 5162077 (1992-11-01), Bryan et al.
patent: 5236570 (1993-08-01), Ma et al.
patent: 5453171 (1995-09-01), Ma et al.
patent: 5607567 (1997-03-01), Yun et al.
patent: WO - 01/88520 (2001-11-01), None
CAS registry record for ETH 500, 2008.
CAS registry record for ETH 2412, 2008.
Ceresa et al., “Direct Potentiometric Information on Total Ionic Concentrations,”Anal. Chem., 2000, vol. 72, pp. 2050-2054.
Culliford et al., “Lack of Correlation between Activated Clotting Time and Plasma Heparin during Cardiopulmonary Bypass,”Ann. Surg., 1981, vol. 193(1), pp. 105-111.
Dai et al., “Bioanalytical Applications of Polyion-Sensitive Electrodes,”J. Pharm. Biomed. Anal., 1999, vol. 19, pp. 1-14.
Despotis et al., “Monitoring of Hemostasis in Cardiac Surgical Patients: Impact of Point-of-Care Testing on Blood Loss and Transfusion Outcomes,”Clin. Chem., 1997, vol. 43(9), pp. 1684-1696.
Fu et al., “Extraction Thermodynamics of Polyanions into Plasticized Polymer membranes Doped with Lipophilic Ion Exchangers: A Potentiometric Study,”Macromolecules, 1995, vol. 28, pp. 5834-5840.
Fu et al., “Polymer Membrane-Based Polyion Sensors: Development, Response Mechanism, and Bioanalytical Applications,”Electroanalysis, 1995, vol. 7(9), pp. 823-829.
Fu et al., “Response Mechanism of Polymer Membrane-Based Potentiometric Polyion Sensors,”Anal. Chem., 1994, vol. 66, pp. 2250-2259.
Han et al., “Selective Monitoring of Peptidase Activities with Synthetic Polypeptide Substrates and Polyion-Sensitive Membrane Electrode Detection,”FASEB J., 1996, vol. 10, pp. 1621-1626.
Hirsh et al., “Heparin: Mechanism of Action, Pharmacokinetics, Dosing Considerations, Monitoring, Efficacy, and Safety,”Chest, 1992, vol. 102(4), Supplement pp. 337S-351S.
Ma et al., “Electrochemical Sensor for Heparin: Further Characterization and Bioanalytical Applications,”Anal. Chem., 1993, vol. 65, pp. 2078-2084.
Ma et al., “Heparin-Responsive Electrochemical Sensor: A Preliminary Study,”Anal. Chem., 1992, vol. 64, pp. 694-697.
Mathison et al., “Renewable pH Cross-Sensitive Potentiometric Heparin Sensors with Incorporated Electrically Charged H+ Ionophores,”Anal. Chem., 1999, vol. 71, pp. 4614-4621.
Meyerhoff et al., “Polyion-Sensitive Membrane,”Anal. Chem., 1996, vol. 68, pp. 168A-175A.
Mi et al., “Polyion Sensors as Liquid Junction-Free Reference Electrodes,” Electrochemical and Solid-State Letters, 1999, vol. 2(4), pp. 198-200.
Oesch et al., “Ion-Selective Membrane Electrodes for Clinical Use,” Clin. Chem., 1986, vol. 32(8), pp. 1448-1459.
Peper et al., “Improved Detection Limits and Sensitivities of Potentiometric Titrations,”Anal. Chem., 2001, vol. 73, pp. 3768-3775.
Qin et al., “Enhanced Sensitivity Electrochemical Assay of Low-Molecular-Weight Heparins Using Rotating Polyion-Sensitive Membrane Electrodes,”Anal. Bioanal. Chem., 2003, vol. 377, pp. 929-936.
Ramamurthy et al., “Improved Protamine-Sensitive Membrane Electrode for Monitoring Heparin Concentrations in Whole Blood via Protamine Titration,”Clin. Chem., 1998, vol. 44(3), pp. 606-613.
Shvarev et al., “Distinguishing Free and Total Calcium with a Single Pulsed Galvanostatic Ion-Selective Electrode,”Talanta, 2004, vol. 63, pp. 195-200.
Shvarev et al., “Pulsed Galvanostatic Control of Ionophore-Based Polymeric Ion Sensors,”Anal. Chem., 2003, vol. 75, pp. 4541-4550.
Shvarev et al., “Reversible Electrochemical Detection of Nonelectroactive Polyions,”J. Am. Chem. Soc., 2003, vol. 125, pp. 11192-11193.
Vigassy et al., “Making Use of Ion Fluxes through Potentiometric Sensor Membranes: ISEs with Step Responses at Critical Ion Activities,”Sens. Actuators B., 2001, vol. 76, pp. 477-482.
Wang et al., “Optical Detection of Macromolecular Heparin via Selective Coextraction into Thin Polymeric Films,”Anal. Chem., 1995, vol. 67, pp. 522-527.
Yun et al., “Electrochemical Sensors for Polyionic Macromolecules: Development and Applications in Pharmaceutical Research,”PSTT, 1999, vol. 2(3), pp. 102-110.
Yun et al., “Protamine-Sensitive Polymer Membrane Electrode: Characterization and Bioanalytical Applications,”Anal. Biochem., 1995, vol. 224, pp. 212-220.
Dürüst et al., “Determination of Pentosan Polysulfate and Its Binding to Polycationic Species Using Polyion-Sensitive Membrane Electrodes,”Analytica Chimica Acta, 2001, vol. 432(2), pp. 253-260.
Bakker et al., “Lipophilicity of Tetraphenylborate Derivatives as Anionic Sites in Neutral Carrier-Based Solvent Polymeric Membranes and Lifetime of Corresponding Ion-Selective Electrochemical and Optical Sensors,”Analytica Chimica Acta, 1995, vol. 309, pp. 7-17.
Lee et al., “Applications of Polyion-Sensitive Electrodes to Pharmaceutical Domain: A Mini-Review,”Journal of Food and Drug Analysis, 2002, vol. 10, No. 4, pp. 212-218.
Lutze et al., “Stabilized Potentiometric Solid-State Polyion Sensors Using Silver-Calixarene Complexes as Additives within Ion-Exchanger-Based Polymeric Films,”Fresenius J. Anal. Chem., 1999, vol. 364, pp. 41-47.
Peper et al., “Ion-Pairing Ability, Chemical Stability, and Selectivity Behavior of Halogenated Dodecacarborane Cation Exchangers in Neutral Carrier-Based Ion-Selective Electrodes,”Anal. Chem., 2003, vol. 75, pp. 2131-2139.
Japanese Office Action, Japanese Patent Office, JP 2006-518878, Jan. 5, 2009.
Korean Office Action, Korean Patent Office, Korean Patent Application No. 10-2006-7000566, Feb. 24, 2009.

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