Reversed phase chromatographic process

Details Reversed phase chromatographic process Reversed phase chromatographic process

1991-01-28

1993-04-20

Bascomb, Jr., Wilbur

Liquid purification or separation

Processes

Chromatography

210635, 424 5, B01D 1508

Patent

active

052040054

ABSTRACT:
An improved process for the reversed phase chromatographic decolorization, separation, and purification of water-soluble, nonionic contrast media compounds from solutions containing nonionic compound impurities involves the steps of (a) packing a chromatographic column with a chromatographic packing material; (b) passing through the column a solution containing a water-soluble, nonionic contrast media compound and nonionic compounds as impurities at a loading ratio between approximately 10 to 1 and 1.5 to 1 wt. packing material/total wt. nonionic compounds; and (c) eluting the column to produce an eluate containing substantially pure, water-soluble, nonionic contrast media compound or MRI agent. The process can be economically practiced on a factory scale and efficiently removes non-polar impurities difficult to remove by conventional methods.

REFERENCES:
patent: 4396598 (1983-08-01), Lin
Nettleton, Jr., "Preparative Liquid Chromatography. I. Approaches Utilizing Highly Compressed Beds. ", Journal of Liquid Chromatography, 4(Suppl. 1), pp. 141-173 (1981).
Jones, K., "Process Scale High Performance Liquid Chromatography Part II; Dissolution of Silica Matrices", Chromatographia vol. 25, No. 5, pp. 443-446, (May 1988).

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