Reversed mammalian protein-protein interaction trap

Details Reversed mammalian protein-protein interaction trap Reversed mammalian protein-protein interaction trap

2009-12-14

2011-11-01

Landsman, Robert (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S007210, C536S023500

Reexamination Certificate

active

08048986

ABSTRACT:
The invention relates to a recombinant receptor, comprising a ligand-binding domain and a signaling domain that comprises a heterologous bait polypeptide, which receptor is inactivated by binding of a prey polypeptide to the heterologous bait peptide, either in presence or absence of a ligand binding to the ligand-binding domain. The receptor is activated by addition of a compound that disrupts the bait-prey interaction. The invention also relates to a method of screening compounds that disrupt compound-compound binding using the recombinant receptor.

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