Reversed geometry MALDI TOF

Details Reversed geometry MALDI TOF Reversed geometry MALDI TOF

2007-05-01

2010-02-16

Wells, Nikita (Department: 2881)

Radiant energy

Ionic separation or analysis

Ion beam pulsing means with detector synchronizing means

C250S281000, C250S282000, C250S286000

Reexamination Certificate

active

07663100

ABSTRACT:
The TOF mass spectrometer disclosed places an even number of ion mirrors in close proximity to a MALDI ion source and a field-free drift space between the exit from the mirrors and an ion detector. This “reversed geometry” configuration may be distinguished from a conventional reflecting TOF analyzer employing a single ion mirror where a large fraction of the total drift space is located between the ion source and the mirror.

REFERENCES:
patent: 4730111 (1988-03-01), Vestal et al.
patent: 4731533 (1988-03-01), Vestal
patent: 4766312 (1988-08-01), Fergusson et al.
patent: 4814612 (1989-03-01), Vestal et al.
patent: 4861989 (1989-08-01), Vestal et al.
patent: 4883958 (1989-11-01), Vestal
patent: 4902891 (1990-02-01), Vestal
patent: 4958529 (1990-09-01), Vestal
patent: 4960992 (1990-10-01), Vestal et al.
patent: 5015845 (1991-05-01), Allen et al.
patent: 5160840 (1992-11-01), Vestal
patent: 5202563 (1993-04-01), Cotter et al.
patent: 5464985 (1995-11-01), Cornish et al.
patent: 5498545 (1996-03-01), Vestal
patent: 5625184 (1997-04-01), Vestal et al.
patent: 5627369 (1997-05-01), Vestal et al.
patent: 5760393 (1998-06-01), Vestal et al.
patent: 6002127 (1999-12-01), Vestal et al.
patent: 6013913 (2000-01-01), Hanson
patent: 6057543 (2000-05-01), Vestal et al.
patent: 6175112 (2001-01-01), Karger et al.
patent: 6281493 (2001-08-01), Vestal et al.
patent: RE37485 (2001-12-01), Vestal
patent: 6348688 (2002-02-01), Vestal
patent: 6414306 (2002-07-01), Mayer-Posner et al.
patent: 6441369 (2002-08-01), Vestal et al.
patent: 6504150 (2003-01-01), Verentchikov et al.
patent: 6512225 (2003-01-01), Vestal et al.
patent: 6534764 (2003-03-01), Verentchikov et al.
patent: 6541765 (2003-04-01), Vestal
patent: 6621074 (2003-09-01), Vestal
patent: 6670609 (2003-12-01), Franzen et al.
patent: 6674070 (2004-01-01), Karger et al.
patent: 6770870 (2004-08-01), Vestal
patent: 6825463 (2004-11-01), Karger et al.
patent: 6831270 (2004-12-01), Furuta et al.
patent: 6844545 (2005-01-01), Hutchins et al.
patent: 6900061 (2005-05-01), Smirnov et al.
patent: 6918309 (2005-07-01), Brock et al.
patent: 6933497 (2005-08-01), Vestal
patent: 6952011 (2005-10-01), Brown et al.
patent: 6953928 (2005-10-01), Vestal et al.
patent: 6995363 (2006-02-01), Donegan et al.
patent: 7030373 (2006-04-01), Vestal et al.
patent: 7064319 (2006-06-01), Hashimoto et al.
patent: 7109480 (2006-09-01), Vestal et al.
patent: RE39353 (2006-10-01), Vestal
patent: 7176454 (2007-02-01), Hayden et al.
patent: 7589319 (2009-09-01), Vestal
patent: 2002/0145109 (2002-10-01), Doroshenko
patent: 2003/0057368 (2003-03-01), Franzen et al.
patent: 2003/0116707 (2003-06-01), Brown et al.
patent: 2003/0141447 (2003-07-01), Verentchikov et al.
patent: 2005/0031496 (2005-02-01), Laurell et al.
patent: 2005/0087685 (2005-04-01), Bouvier et al.
patent: 2005/0130222 (2005-06-01), Lee et al.
patent: 2005/0178959 (2005-08-01), Lopez-Avila et al.
patent: 2005/0269505 (2005-12-01), Ermer
patent: 2006/0266941 (2006-11-01), Vestal
patent: 2006/0273252 (2006-12-01), Hayden et al.
patent: 2007/0038387 (2007-02-01), Chen et al.
patent: 2007/0054416 (2007-03-01), Regnier et al.
patent: 2008/0272290 (2008-11-01), Vestal
patent: 2008/0272291 (2008-11-01), Vestal
patent: 2009/0026365 (2009-01-01), Satoh
patent: 2 370 114 (2002-06-01), None
patent: WO 2004/018102 (2004-03-01), None
patent: WO 2005/061111 (2005-07-01), None
R. Kaufmann, et al., “Sequencing of Peptides in a Time-of-Flight Mass Spectrometer-Evaluation of Postsource Decay . . . ,” Int. J. Mass Spectrom. Ion Process. 131: 355-385 (1994).
J. Preisler, et al., “Capillary Array Electrophoresis-MALDI Mass Spectrometry using a Vacuum Deposition Interface,” Anal. Chem. 74: 17-25 (2002).
R. L. Caldwell and R. M. Caprioli, “Tissue Profiling by Mass Spectrometry,” MCP 4: 394-401 (2005).
M. L. Vestal, et al., “Delayed Extraction Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry,” Rapid Comm. Mass Spectrom. 9: 1044-1050 (1995).
M. L. Vestal and P. Juhasz, “Resolution and Mass Accuracy in Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry,” J. Am. Soc. Mass Spectrom. 9: 892-911 (1998).
E. J. Takach, et al., “Accurate Mass Measurement using MALDI-TOF with Delayed Extraction,” J. Prot. Chem. 16: 363-369 (1997).
D. J. Beussman, et al., “Tandem Reflectron Time-of-Flight Mass Spectrometer Utilizing Photodissociation,” Anal. Chem. 67: 3952-3957 (1995).
M. L. Vestal, “High-Performance Liquid Chromatography-Mass Spectrometry,” Science 226: 275-281 (1984).

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