Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-09-04
1999-09-21
Elliott, George C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4352542, 4353201, 435325, 536 231, 536 241, C07H 2104, C12N 119, C12N 510, C12Q 168
Patent
active
059552808
ABSTRACT:
Disclosed are methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ counterselection and at least two hybrid molecules. Molecules which interact reconstitute a transcription factor and direct expression of a reporter gene, the expression of which is then assayed. Also disclosed are genetic constructs which are useful in practicing the methods of the invention.
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Boeke Jef D.
Harlow Ed
Vidal Marc
Elliott George C.
Schwartzman Robert
The General Hospital Corporation
The Johns Hopkins University
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