Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-06-06
1997-03-25
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514555, 514576, A61K 31255, A61K 31185
Patent
active
056145543
ABSTRACT:
The present invention provides a reverse transcriptase inhibitor and an antiviral agent comprising at least one member selected from the group consisting of sulfated tyrosines and physiologically acceptable salts thereof as an effective component; and exhibiting less toxicity and a remarkable inhibitory effect against a reverse transcriptase existing in viruses as well as a remarkable anti-AIDS viral activity.
REFERENCES:
Yoshikawa et al., CA: 85-160,525h ((1976) (Abstract of Japan Kokai 76 22,817) (1976).
Yoshikawa et al. CA: 80-6,962p (1974).
Patent Abstracts of Japan, vol. 14, No. 453(C-764)[43961], Sep. 28, 1990, JP-A-2-178232, Jul. 11, 1990.
Journal of the American Chemical Society, vol. 68, pp. 1024-1031, Jun. 1990, H.C. Reitz, et al., "Action of Sulfating Agents on Proteins and Model Substances. I. Concentrated Sulfuric Acid.".
Liu, Ming-Cheh et al, "Tyramine-O-Sulfate, In Addition to Tyrosine-O-Sulfate, is Produced and Secreted by HepG2 Human Hepatoma Cells, But Not by 3Y1 Rat Embryo Fibroblasts," Biochem. Int., vol. 21, No. 5, pp. 815-821 (1990).
Saida, T. et al, "Formation of Tyrosine O-Sulfate by Mitochondria and Chloroplasts of Euglena," Arch. Biochem. Biophys., vol. 272, pp. 237-244 (1989).
W. P. Huttner, "Determination and Occurrence of Tyrosine O-Sulfate in Proteins," Methods in Enzymology, vol. 107, pp. 200-223 (1984).
F. R. Bettelheim, "Communications to the Editor," J. Am. Chem. Soc., vol. 76, p. 2838 (1954).
L. Moroder et al, "Lynthese von Tyrosin-O-sulfat-haltigen Peptiden", Hoppe-Seyler's Z. Physiol. Chem, vol. 360, p. 787 (1979).
H.C. Reitz, et al, "Action of Sulfating Agents on Proteins and Model Substances," J. Am. Chem. Soc., vol. 68, p. 1024 (1946).
Mizuno Takashi
Murakami Sachie
Nakashima Hideki
Ogawara Hiroshi
Uchino Keijiro
Chan Nicky
Nippon Flour Mills Co., Ltd.
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