Reverse transcriptase inhibitors and antiviral agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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514555, 514576, A61K 31255, A61K 31185

Patent

active

056145543

ABSTRACT:
The present invention provides a reverse transcriptase inhibitor and an antiviral agent comprising at least one member selected from the group consisting of sulfated tyrosines and physiologically acceptable salts thereof as an effective component; and exhibiting less toxicity and a remarkable inhibitory effect against a reverse transcriptase existing in viruses as well as a remarkable anti-AIDS viral activity.

REFERENCES:
Yoshikawa et al., CA: 85-160,525h ((1976) (Abstract of Japan Kokai 76 22,817) (1976).
Yoshikawa et al. CA: 80-6,962p (1974).
Patent Abstracts of Japan, vol. 14, No. 453(C-764)[43961], Sep. 28, 1990, JP-A-2-178232, Jul. 11, 1990.
Journal of the American Chemical Society, vol. 68, pp. 1024-1031, Jun. 1990, H.C. Reitz, et al., "Action of Sulfating Agents on Proteins and Model Substances. I. Concentrated Sulfuric Acid.".
Liu, Ming-Cheh et al, "Tyramine-O-Sulfate, In Addition to Tyrosine-O-Sulfate, is Produced and Secreted by HepG2 Human Hepatoma Cells, But Not by 3Y1 Rat Embryo Fibroblasts," Biochem. Int., vol. 21, No. 5, pp. 815-821 (1990).
Saida, T. et al, "Formation of Tyrosine O-Sulfate by Mitochondria and Chloroplasts of Euglena," Arch. Biochem. Biophys., vol. 272, pp. 237-244 (1989).
W. P. Huttner, "Determination and Occurrence of Tyrosine O-Sulfate in Proteins," Methods in Enzymology, vol. 107, pp. 200-223 (1984).
F. R. Bettelheim, "Communications to the Editor," J. Am. Chem. Soc., vol. 76, p. 2838 (1954).
L. Moroder et al, "Lynthese von Tyrosin-O-sulfat-haltigen Peptiden", Hoppe-Seyler's Z. Physiol. Chem, vol. 360, p. 787 (1979).
H.C. Reitz, et al, "Action of Sulfating Agents on Proteins and Model Substances," J. Am. Chem. Soc., vol. 68, p. 1024 (1946).

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